Literature DB >> 7115345

Evidence for a high fatty acid synthesis activity in interscapular brown adipose tissue of genetically obese Zucker rats.

M Lavau, R Bazin, Z Karaoghlanian, C Guichard.   

Abstract

Obese (fa/fa) rats (30 days old) exhibited a 50% increase in the weight of interscapular brown adipose tissue compared with their lean (Fa/fa) littermates. The tissue weight increase was accounted for by an increased fat content. Lipogenesis in vivo, as assessed by the incorporation of 3H from 3H2O into lipid, was increased 5-fold in brown adipose tissue of obese as compared with lean rats. Accordingly, acetyl-CoA carboxylase, fatty acid synthetase, citrate-cleavage enzyme and malic enzyme in this tissue were 4-8 times more active in obese than in lean rats.

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Year:  1982        PMID： 7115345      PMCID： PMC1158378          DOI： 10.1042/bj2040503

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

Authors:  D Stansbie; R W Brownsey; M Crettaz; R M Denton
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

2.  Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver.

Authors:  G E GLOCK; P McLEAN
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

3.  The mechanism of tricarboxylic acid cycle regulation of fatty acid synthesis.

Authors:  D B MARTIN; P R VAGELOS
Journal:  J Biol Chem       Date:  1962-06       Impact factor: 5.157

4.  Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase.

Authors:  J G McCormack; R M Denton
Journal:  Biochem J       Date:  1977-09-15       Impact factor: 3.857

5.  The sulfhydryl groups of citrate cleavage enzyme.

Authors:  G L Cottam; P A Srere
Journal:  Arch Biochem Biophys       Date:  1969-03       Impact factor: 4.013

6.  Developmental changes in the fatty (fafa) rat: evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinaemia.

Authors:  V Godbole; D A York; D P Bloxham
Journal:  Diabetologia       Date:  1978-07       Impact factor: 10.122

7.  Fatty acid synthesis in mouse brown adipose tissue. The influence of environmental temperature on the proportion of whole-body fatty acid synthesis in brown adipose tissue and the liver.

Authors:  P Trayhurn
Journal:  Biochim Biophys Acta       Date:  1981-06-23

8.  Onset and development of hypertriglyceridemia in the Zucker rat (fa/fa).

Authors:  A Boulangé; E Planche; P de Gasquet
Journal:  Metabolism       Date:  1981-11       Impact factor: 8.694

9.  Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase.

Authors:  A P Halestrap; R M Denton
Journal:  Biochem J       Date:  1973-03       Impact factor: 3.857

10.  GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states.

Authors:  A E Goodbody; P Trayhurn
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857
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  9 in total

1.  Tissue-specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats.

Authors:  J R Gorski; L W Weber; K Rozman
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

2.  The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa).

Authors:  S Holt; D A York; J T Fitzsimons
Journal:  Biochem J       Date:  1983-07-15       Impact factor: 3.857

3.  Thermogenic and lipogenic activities in brown adipose tissue of I-strain mice.

Authors:  R Bazin; D Ricquier; F Dupuy; J Hoover-Plow; M Lavau
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

4.  Lipid metabolism in the obese Zucker rat. Disposal of an oral [14C]triolein load and lipoprotein lipase activity.

Authors:  E J López-Soriano; N Carbó; J M Argilés
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

5.  Evidence for decreased GDP binding to brown-adipose-tissue mitochondria of obese Zucker (fa/fa) rats in the very first days of life.

Authors:  R Bazin; D Eteve; M Lavau
Journal:  Biochem J       Date:  1984-07-01       Impact factor: 3.857

6.  The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat.

Authors:  S Holt; D A York
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

7.  Development of fatty acid-synthetic capacity in interscapular brown adipose tissue during suckling in genetically obese Zucker rats.

Authors:  R Bazin; M Lavau; C Guichard
Journal:  Biochem J       Date:  1983-12-15       Impact factor: 3.857

8.  Developmental changes in fatty acid synthesis in interscapular brown adipose tissue of lean and genetically obese (ob/ob) mice.

Authors:  S W Mercer; P Trayhurn
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857

9.  Changes in the lipogenic response to feeding of liver, white adipose tissue and brown adipose tissue during the development of obesity in the gold-thioglucose-injected mouse.

Authors:  G J Cooney; M A Vanner; J L Nicks; P F Williams; I D Caterson
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857
  9 in total

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