Literature DB >> 6615467

The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa).

S Holt, D A York, J T Fitzsimons.   

Abstract

GDP binding to brown-adipose-tissue mitochondria was decreased in obese Zucker rats. Adrenalectomy restored both GDP binding and serum tri-iodothyronine of obese rats to values observed in lean rats. The effects of adrenalectomy on GDP binding and serum tri-iodothyronine were reversed by corticosterone. Decreasing food intake had no effect on brown-adipose-tissue GDP binding in obese rats. Young (5-week-old) obese rats showed a normal increase in brown-adipose-tissue mitochondrial GDP binding after housing at 4 degrees C for 7 days, but this response was attenuated in 10-week-old obese rats. Overfeeding with sucrose increased brown-adipose-tissue thermogenesis in lean, but not in obese, rats. After adrenalectomy, overfeeding with sucrose enhanced brown-adipose-tissue mitochondrial GDP binding in obese rats.

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Year:  1983        PMID： 6615467      PMCID： PMC1152229          DOI： 10.1042/bj2140215

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  41 in total

1.  A role for brown adipose tissue in diet-induced thermogenesis.

Authors:  N J Rothwell; M J Stock
Journal:  Nature       Date:  1979-09-06       Impact factor: 49.962

2.  Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice.

Authors:  P Trayhurn; P M Jones; M M McGuckin; A E Goodbody
Journal:  Nature       Date:  1982-01-28       Impact factor: 49.962

3.  Abnormal brown adipose tissue in obese (ob/ob) mice: response to acclimation to cold.

Authors:  S Hogan; J Himms-Hagen
Journal:  Am J Physiol       Date:  1980-10

4.  Thyroid status and effects of 3,5,3' triiodothyroacetic acid and fenproporex in genetically lean and obese female rats.

Authors:  N Autissier; P Dumas; A Loireau; R Michel
Journal:  Biochem Pharmacol       Date:  1980-06-01       Impact factor: 5.858

5.  Effects of feeding a palatable "cafeteria' diet on energy balance in young and adult lean (+/?) Zucker rats.

Authors:  N J Rothwell; M J Stock
Journal:  Br J Nutr       Date:  1982-05       Impact factor: 3.718

6.  Photoperiodic regulation of growth: a photosensitive phase during light-dark cycle.

Authors:  B D Schanbacher; J D Crouse
Journal:  Am J Physiol       Date:  1981-07

7.  Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis.

Authors:  S L Brooks; N J Rothwell; M J Stock; A E Goodbody; P Trayhurn
Journal:  Nature       Date:  1980-07-17       Impact factor: 49.962

8.  The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat.

Authors:  S Holt; D A York
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

9.  Abnormal sympatho- adrenal function and plasma catecholamines in obese Zucker rats.

Authors:  B E Levin; J Triscari; A C Sullivan
Journal:  Pharmacol Biochem Behav       Date:  1980-07       Impact factor: 3.533

10.  GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states.

Authors:  A E Goodbody; P Trayhurn
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857
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  7 in total

Review 1.  Leptin: at the crossroads of energy balance and systemic inflammation.

Authors:  Alexandre A Steiner; Andrej A Romanovsky
Journal:  Prog Lipid Res       Date:  2006-12-21       Impact factor: 16.195

Review 2.  Body fat and sympathetic nerve activity.

Authors:  U Scherrer; R Owlya; M Lepori
Journal:  Cardiovasc Drugs Ther       Date:  1996-06       Impact factor: 3.727

3.  Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.

Authors:  M Spraul; E Ravussin; A M Fontvieille; R Rising; D E Larson; E A Anderson
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

4.  Effect of corticotropin on brown adipose tissue mitochondrial GDP binding in obese rats.

Authors:  D A York; I Al-Baker
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

5.  Evidence for decreased GDP binding to brown-adipose-tissue mitochondria of obese Zucker (fa/fa) rats in the very first days of life.

Authors:  R Bazin; D Eteve; M Lavau
Journal:  Biochem J       Date:  1984-07-01       Impact factor: 3.857

6.  Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.

Authors:  P Vollenweider; D Randin; L Tappy; E Jéquier; P Nicod; U Scherrer
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

7.  Alpha 1- and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy.

Authors:  A Raasmaja; D A York
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857
  7 in total

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