Literature DB >> 705775

The affected sib pair IBD distribution for HLA-linked disease susceptibility genes.

B K Suarez.   

Abstract

The distribution of identity by descent (IBD) scores for sib pairs affected with a disease determined by a disease susceptibility (DS) locus tightly linked to the HLA complex is derived. It is shown that the sib pair IBD distribution differs from its a priori distribution and, moreover, is completely specified by three observable population parameters--the additive and dominance variances and the prevalence of the disease in the population. An application of the model is illustrated using data on juvenile diabetes mellitus.

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Year:  1978        PMID： 705775     DOI： 10.1111/j.1399-0039.1978.tb01303.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  15 in total

1.  Analysis of affected sib pairs, with covariates--with and without constraints.

Authors:  C M Greenwood; S B Bull
Journal:  Am J Hum Genet       Date:  1999-03       Impact factor: 11.025

2.  A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search.

Authors:  S L Smalley; J A Woodward; C G Palmer
Journal:  Am J Hum Genet       Date:  1996-04       Impact factor: 11.025

Review 3.  Software for genetic linkage analysis: an update.

Authors:  S P Bryant
Journal:  Mol Biotechnol       Date:  1996-02       Impact factor: 2.695

4.  Conclusion of LOD-score analysis for family data generated under two-locus models.

Authors:  M H Dizier; M C Babron; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

5.  Consanguinity and the sib-pair method: an approach using identity by descent between and within individuals.

Authors:  E Génin; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

6.  Determining the mode of inheritance of RFLP-associated diseases using the affected sib-pair method.

Authors:  G Thomson
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

7.  The affected sib method. III. Selection and recombination.

Authors:  H Payami; G Thomson; E J Louis
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

8.  The utility of simplex sibships in the characterization of HLA-linked disease susceptibility genes.

Authors:  R M Sharp; J W Templeton
Journal:  Am J Hum Genet       Date:  1984-07       Impact factor: 11.025

9.  The genotypic distribution among non-insulin-dependent diabetes mellitus (NIDDM) patients of a restriction fragment length polymorphism.

Authors:  G Thomson
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

10.  Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.

Authors:  S E Hodge
Journal:  Am J Hum Genet       Date:  1993-08       Impact factor: 11.025
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