Literature DB >> 6475957

The utility of simplex sibships in the characterization of HLA-linked disease susceptibility genes.

R M Sharp, J W Templeton.   

Abstract

We demonstrate, by plotting the deviations from expected ratios of identity by descent (IBD) scores of sibling pairs having only one affected individual, that simplex pairs can, under certain constraints, provide a rich source of information concerning linkage relationships of a disease susceptibility gene. In addition, two statistical tests of significance are presented, one for a fixed sample size and a second for a sequential sampling approach.

Mesh：

Substances：

Year:  1984        PMID： 6475957      PMCID： PMC1684478     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  8 in total

1.  The detection of the genetic carriers of hereditary disease.

Authors:  J V Neel
Journal:  Am J Hum Genet       Date:  1949-09       Impact factor: 11.025

2.  Disease susceptibility genes--their identification by multiple case family studies.

Authors:  N E Day; M J Simons
Journal:  Tissue Antigens       Date:  1976-08

3.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

4.  Sibling Method for Detecting HLA-linked genes in disease.

Authors:  J R Green; J C Woodrow
Journal:  Tissue Antigens       Date:  1977-01

5.  The generalized sib pair IBD distribution: its use in the detection of linkage.

Authors:  B K Suarez; J Rice; T Reich
Journal:  Ann Hum Genet       Date:  1978-07       Impact factor: 1.670

6.  A robust method for the detection of linkage in familial disease.

Authors:  P M Fishman; B Suarez; S E Hodge; T Reich
Journal:  Am J Hum Genet       Date:  1978-05       Impact factor: 11.025

7.  The affected sib pair IBD distribution for HLA-linked disease susceptibility genes.

Authors:  B K Suarez
Journal:  Tissue Antigens       Date:  1978-08

Review 8.  Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis.

Authors:  R D Rossen; E J Brewer; R M Sharp; J Ott; J W Templeton
Journal:  J Clin Invest       Date:  1980-03       Impact factor: 14.808
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.