Literature DB >> 7057191

Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain.

C J Fowler, K F Tipton.   

Abstract

Km and Vmax values of monoamine oxidase (MAO) A and B towards 5-hydroxytryptamine were determined for rat brain homogenates after the in vitro inhibition of one of the two forms by the selective inhibitors clorgyline and l-deprenyl. Km values of 178 and 1170 microM, and Vmax values of 0.73 and 0.09 nmol . mg protein-1 . min-1 towards 5-hydroxytryptamine were found for MAO-A and -B, respectively. The Ki for 5-hydroxytryptamine as a competitive inhibitor of beta-phenethylamine oxidation by MAO-B was found to be 1400 microM. The significance of these findings is discussed.

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Year:  1982        PMID： 7057191     DOI： 10.1111/j.1471-4159.1982.tb08692.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  29 in total

1.  Relationship between extracellular 5-hydroxytryptamine and behaviour following monoamine oxidase inhibition and L-tryptophan.

Authors:  A J Sleight; C A Marsden; K F Martin; M G Palfreyman
Journal:  Br J Pharmacol       Date:  1988-02       Impact factor: 8.739

2.  [3H]5-HT binding in post-mortem human cerebral cortex: methodological considerations.

Authors:  S C Cheetham; R W Horton
Journal:  J Neural Transm Gen Sect       Date:  1989

3.  The effect of selective type A or type B monoamine oxidase inhibition on the intrasynaptosomal deamination of (3H)serotonin in rat spinal cord tissue.

Authors:  A J Azzaro; J B Amedro; L M Brown; D J Smith; G M Williams
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-07       Impact factor: 3.000

4.  Monoamine oxidase inhibitors increase preferentially extracellular 5-hydroxytryptamine in the midbrain raphe nuclei. A brain microdialysis study in the awake rat.

Authors:  P Celada; F Artigas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-06       Impact factor: 3.000

5.  In vivo evidence for the reversible action of the monoamine oxidase inhibitor brofaromine on 5-hydroxytryptamine release in rat brain.

Authors:  N Bel; F Artigas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

6.  Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline.

Authors:  Z Speiser; T Fine; L Litinetsky; S Eliash; E Blaugrund; S Cohen
Journal:  J Neural Transm (Vienna)       Date:  2007-09-07       Impact factor: 3.575

7.  The activity of monoamine oxidase -A and -B in brains from chronic alcoholics.

Authors:  L Oreland; A Wiberg; B Winblad; C J Fowler; C G Gottfries; K Kiianmaa
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

8.  Sympathetic denervation and chronic serotonin uptake blockade by fluoxetine do not affect pineal gland 5-hydroxyindole acetic acid: evidence that oxidative deamination of pineal serotonin is a property of the pinealocyte.

Authors:  J A McNulty; V Colin
Journal:  J Neural Transm Gen Sect       Date:  1992

9.  In vivo, noradrenaline is a substrate for rat brain monoamine oxidase A and B.

Authors:  M B Youdim
Journal:  Br J Pharmacol       Date:  1983-06       Impact factor: 8.739

10.  Behavioural hyperactivity in rats treated with selective monoamine oxidase inhibitors and LM 5008, a selective 5-hydroxytryptamine uptake blocker.

Authors:  R Ashkenazi; J P Finberg; M B Youdim
Journal:  Br J Pharmacol       Date:  1983-07       Impact factor: 8.739
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