Literature DB >> 7053304

Altered hydroxydesipramine concentrations in elderly depressed patients.

I Kitanaka, R J Ross, N R Cutler, A P Zavadil, W Z Potter.   

Abstract

Recent reports demonstrate that hydroxy metabolites of desipramine (DMI) have pharmacologic activity and do not just produce side effects. In patients treated with DMI, we determined the ratio of 2-hydroxydesipramine (2-OH-DMI) to drug at steady state. The ratios in the elderly patients were higher than in younger patients, and whereas plasma levels of 2-OH-DMI increased with age, urinary clearances decreased. The known decrease in glomerular filtration with age may explain the selective increase of 2-OH-DMI concentration in the elderly.

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Year:  1982        PMID： 7053304     DOI： 10.1038/clpt.1982.8

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  12 in total

Review 1.  Adverse effects of antidepressants in the elderly.

Authors:  L Nolan; K O'Malley
Journal:  Drugs Aging       Date:  1992 Sep-Oct       Impact factor: 3.923

2.  Monitoring tricyclic antidepressant therapy.

Authors:  M V Rudorfer
Journal:  Pharmacoeconomics       Date:  1992-02       Impact factor: 4.981

Review 3.  Pharmacokinetic optimisation of tricyclic antidepressant therapy.

Authors:  M Furlanut; P Benetello; E Spina
Journal:  Clin Pharmacokinet       Date:  1993-04       Impact factor: 6.447

Review 4.  Drug-induced orthostatic hypotension in the elderly: avoiding its onset.

Authors:  I Verhaeverbeke; T Mets
Journal:  Drug Saf       Date:  1997-08       Impact factor: 5.606

Review 5.  The Role of Metabolites of Antidepressants in the Treatment of Depression.

Authors:  M V Rudorfer; W Z Potter
Journal:  CNS Drugs       Date:  1997-04       Impact factor: 5.749

6.  Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Authors:  M V Rudorfer; E A Lane; W H Chang; M D Zhang; W Z Potter
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

Review 7.  Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications.

Authors:  L L von Moltke; D J Greenblatt; R I Shader
Journal:  Clin Pharmacokinet       Date:  1993-02       Impact factor: 6.447

Review 8.  Metabolism of tricyclic antidepressants.

Authors:  M V Rudorfer; W Z Potter
Journal:  Cell Mol Neurobiol       Date:  1999-06       Impact factor: 5.046

9.  Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine.

Authors:  B G Pollock; J M Perel
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 10.  Clinical pharmacokinetic considerations in the elderly. An update.

Authors:  S Dawling; P Crome
Journal:  Clin Pharmacokinet       Date:  1989-10       Impact factor: 6.447
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