Literature DB >> 7052344

The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors.

P R Golds, F R Przyslo, P G Strange.   

Abstract

1 The binding of some antidepressant drugs, including some new drugs of atypical structure (flupenthixol, iprindole, maprotiline, mianserin, nomifensine, tofenacine and viloxazine) to muscarinic acetylcholine receptors in the brain has been studied by displacement of [3H]-atropine. 2 Many of the drugs are potent muscarinic antagonists. 3 Some correlation can be made between the affinity for binding to the muscarinic acetylcholine receptor and the incidence of anticholinergic side effects in clinical usage.

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Year:  1980        PMID： 7052344      PMCID： PMC2044199          DOI： 10.1111/j.1476-5381.1980.tb14570.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  30 in total

1.  The nature of (3H)imipramine binding to synaptosomes.

Authors:  P F Hunt; M H Kannengiesser; J P Raynaud
Journal:  Biochem Pharmacol       Date:  1975-03-15       Impact factor: 5.858

2.  THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.

Authors:  W D PATON; H P RANG
Journal:  Proc R Soc Lond B Biol Sci       Date:  1965-08-24

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Comparative studies on the membrane actions of depressant drugs: the role of lipophilicity in inhibition of brain sodium and potassium-stimulated ATPase.

Authors:  B D Roufogalis
Journal:  J Neurochem       Date:  1975-01       Impact factor: 5.372

5.  Letter: A rapid assay of affinity for the narcotic receptor in rat brain: application to methadone analogues.

Authors:  L Terenius
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1974-01

6.  Clinical trial of a new antidepressant (WY.3263). With assessment of doctor-patient interaction.

Authors:  N K el-Deiry; A D Forrest; S K Littmann
Journal:  Br J Psychiatry       Date:  1967-09       Impact factor: 9.319

7.  Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine.

Authors:  A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1969-03       Impact factor: 4.432

8.  Effects of imipramine on the Na+-dependent exchange and retention of gamma-aminobutyric acid by mouse brain subcellular particles.

Authors:  H Weinstein; S Varon; E Roberts
Journal:  Biochem Pharmacol       Date:  1971-01       Impact factor: 5.858

9.  Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism.

Authors:  R J Miller; C R Hiley
Journal:  Nature       Date:  1974-04-12       Impact factor: 49.962

10.  Uptake mechanisms for neurotransmitter amines.

Authors:  L L Iversen
Journal:  Biochem Pharmacol       Date:  1974-07-15       Impact factor: 5.858
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  16 in total

1.  Binding affinities of four tricyclic antidepressive drugs to muscarinic cholinergic receptors in human parotid gland.

Authors:  S Batra; A Biörklund
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Heterogeneity of D2 dopamine receptors in different brain regions.

Authors:  M N Leonard; C A Macey; P G Strange
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

Review 3.  Acetylcholine and affective disorder.

Authors:  S S Leong; W A Brown
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

4.  Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels.

Authors:  L Clemmesen; P L Mikkelsen; H Lund; T G Bolwig; O J Rafaelsen
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

5.  The interaction of trazodone with rat brain muscarinic cholinoceptors.

Authors:  D K Hyslop; D P Taylor
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

6.  Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.

Authors:  E El-Fakahany; E Richelson
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

7.  The effects of noradrenergic denervation on muscarinic receptors of smooth muscle.

Authors:  T Bennett; T Y Lot; P G Strange
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

8.  The effect of some antidepressants on prejunctional muscarinic receptors on the sympathetic nerves of the isolated rabbit ear artery.

Authors:  Y H Kwok; F Mitchelson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-07       Impact factor: 3.000

9.  Antagonism of oxotremorine-induced behavioral suppression by antimuscarinic drugs.

Authors:  J D Leander
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Involvement of the amygdala in the effect of antidepressants on the passive avoidance deficit in bulbectomised rats.

Authors:  D Garrigou; C L Broekkamp; K G Lloyd
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
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