Literature DB >> 7470750

The interaction of trazodone with rat brain muscarinic cholinoceptors.

D K Hyslop, D P Taylor.   

Abstract

The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the muscarinic acetylcholine binding site in comparison to the tricyclic antidepressants.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7470750      PMCID： PMC2044452          DOI： 10.1111/j.1476-5381.1980.tb10947.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Proceedings: Trazodone: clinical and biochemical studies II. Blood levels and therapeutic responsiveness.

Authors:  S Putzolu; J C Pecknold; L Baiocchi
Journal:  Psychopharmacol Bull       Date:  1976-01

2.  Antidepressants and the muscarinic acetylcholine receptor.

Authors:  S H Snyder; H I Yamamura
Journal:  Arch Gen Psychiatry       Date:  1977-02

3.  Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines.

Authors:  W Burgermeister; W L Klein; M Nirenberg; B Witkop
Journal:  Mol Pharmacol       Date:  1978-09       Impact factor: 4.436

4.  Desipramine plasma levels and clinical response in depressed outpatients.

Authors:  R O Friedel; R C Veith; V Bloom; R J Bielski
Journal:  Commun Psychopharmacol       Date:  1979

5.  The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors.

Authors:  P R Golds; F R Przyslo; P G Strange
Journal:  Br J Pharmacol       Date:  1980-03       Impact factor: 8.739

6.  Lack of anticholinergic side effects with a new antidepressent--trazodone.

Authors:  S Gershon; R Newton
Journal:  J Clin Psychiatry       Date:  1980-03       Impact factor: 4.384

7.  Trazodone, a new nontricyclic antidepressant without anticholinergic activity.

Authors:  D P Taylor; D K Hyslop; L A Riblet
Journal:  Biochem Pharmacol       Date:  1980-08-01       Impact factor: 5.858

8.  Amitriptyline plasma levels and therapeutic response.

Authors:  V E Ziegler; B T Co; J R Taylor; P J Clayton; J T Biggs
Journal:  Clin Pharmacol Ther       Date:  1976-06       Impact factor: 6.875

9.  Trazodone, a new antidepressant: efficacy and safety in endogenous depression.

Authors:  J J Kellams; M H Klapper; J G Small
Journal:  J Clin Psychiatry       Date:  1979-09       Impact factor: 4.384
  9 in total
  4 in total

Review 1.  Acetylcholine and affective disorder.

Authors:  S S Leong; W A Brown
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

2.  Pharmacokinetic and pharmacodynamic characteristics of a controlled-release formulation of trazodone versus the conventional formulation in healthy volunteers.

Authors:  P Monteleone; G Delrio
Journal:  Ital J Neurol Sci       Date:  1993-09

3.  Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.

Authors:  E El-Fakahany; E Richelson
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

4.  A comparison of two oral dosage regimens of 150 mg trazodone in the treatment of depression in general practice.

Authors:  A Davey
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.