Literature DB >> 7049287

Effect of dipyridamole on the formation of 6-oxo-prostaglandin F1 alpha by the rat isolated aorta and ram seminal vesicle microsomes.

H Bult, A G Herman, V J Van de Velde.   

Abstract

1 Dipyridamole (1 and 10 muM) enhanced the production of 6-oxo-prostaglandin F1 alpha by rat aortic tissue. 2 Dipyridamole (5 to 40 muM) did not influence the PGI2-synthetase activity in ram seminal vesicle microsomes whereas, in concentrations ranging from 100 to 200 muM, it reduced the metabolism of exogenously added arachidonic acid. The latter effect may be due to an inhibition of the cyclooxygenase.

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Year:  1982        PMID： 7049287      PMCID： PMC2071805          DOI： 10.1111/j.1476-5381.1982.tb09239.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase.

Authors:  C Takeguchi; E Kono; C J Sih
Journal:  Biochemistry       Date:  1971-06-08       Impact factor: 3.162

2.  Antioxidants increase the formation of 6-oxo-PGF1 alpha by ram seminal vesicle microsomes.

Authors:  J R Beetens; M Claeys; A G Herman
Journal:  Biochem Pharmacol       Date:  1981-10       Impact factor: 5.858

3.  Bioequivalence of two dipyridamole preparations and inhibitory effect on the platelet adenosine uptake in man.

Authors:  C Chevolet; V Van de Velde; H Weisenberger; A Herman; A Dresse
Journal:  Arch Int Pharmacodyn Ther       Date:  1981-10

4.  A study of three vasodilating agents as selective inhibitors of thromboxane A2 biosynthesis.

Authors:  J E Greenwald; L K Wong; M Rao; J R Bianchine; R V Panganamala
Journal:  Biochem Biophys Res Commun       Date:  1978-10-30       Impact factor: 3.575

5.  The metabolism of arachidonic acid is changed by dipyridamole in isolated hamster lungs.

Authors:  P Uotila; J Männistö
Journal:  Prostaglandins Med       Date:  1981-07

6.  Dipyridamole: a potent stimulator of prostacyclin (PGI2) biosynthesis.

Authors:  K E Blass; H U Block; W Förster; K Pönicke
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739

7.  A radioimmunoassay for 6-keto-prostaglandin F1alpha.

Authors:  J A Salmon
Journal:  Prostaglandins       Date:  1978-03

8.  The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets.

Authors:  D C Mills; J B Smith
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

9.  Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin.

Authors:  S Moncada; R Korbut
Journal:  Lancet       Date:  1978-06-17       Impact factor: 79.321

10.  The interaction of varying doses of dipyridamole and acetyl salicylic acid on the inhibition of platelet functions and their effect on bleeding time.

Authors:  S M Rajah; A F Penny; M J Crow; M D Pepper; D A Watson
Journal:  Br J Clin Pharmacol       Date:  1979-11       Impact factor: 4.335
  10 in total
  1 in total

1.  The role of endothelial cells in the relaxations induced by 13-hydroxy- and 13-hydroperoxylinoleic acid in canine arteries.

Authors:  G R De Meyer; H Bult; T J Verbeuren; A G Herman
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
  1 in total

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