Literature DB >> 6766769

Dipyridamole: a potent stimulator of prostacyclin (PGI2) biosynthesis.

K E Blass, H U Block, W Förster, K Pönicke.   

Abstract

1 Dipyridamole (0.01 to 0.75 mM) increased prostacyclin (PGI2) biosynthesis from tritiated arachidonic acid in rat stomach fundus homogenates by 21 to 350%. The transformation of prostaglandin H2 (PGH2) to PGI2 by a microsomal fraction of pig aorta was stimulated by dipyridamole at 0.1 M by 63%. 2 In the isolated perfused heart of the rabbit dipyridamole at 1 and 5 micrograms/ml increased PGI2 release by 70% and 146% respectively. 3 Our results show a stimulation of the second step in PGI2 biosynthesis (from endoperoxides) by dipyridamole. This effect should be considered in relation to the therapeutic usage of the drug in myocardial infarction.

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Year:  1980        PMID： 6766769      PMCID： PMC2044099          DOI： 10.1111/j.1476-5381.1980.tb10700.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  [COMPETITIVE INHIBITION OF CATALYZED ADENOSINE DIFFUSION AS THE MECHANISM OF THE CORONARY DILATING EFFECT OF A PYRIMIDO-PYRIMIDINE DERIVATIVE].

Authors:  W KUEBLER; H J BRETSCHNEIDER
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1964-07-01

2.  [Pharmacological properties of a new coronary dilator substance 2, 6-bis(diethanolamino)-4, 8-dipiperidino-pyrimido[5,4-d]pyrimidine].

Authors:  R KADATZ
Journal:  Arzneimittelforschung       Date:  1959-01

3.  Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.

Authors:  E A de Deckere; D H Nugteren; F Ten Hoor
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

4.  Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia.

Authors:  A M Lefer; M L Ogletree; J B Smith; M J Silver; K C Nicolaou; W E Barnette; G P Gasic
Journal:  Science       Date:  1978-04-07       Impact factor: 47.728

5.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

6.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962
  6 in total
  19 in total

1.  The antiarrhythmic effects of the nucleoside transporter inhibitor, R75231, in anaesthetized pigs.

Authors:  C L Wainwright; J R Parratt; H Van Belle
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

2.  Platelet involvement in the nephritis of acute serum sickness in rabbits: protection by dipyridamole and FUT-175.

Authors:  A Koyama; H Inage; M Sano; M Narita; S Tojo; G H Neild; J S Cameron
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

3.  Inhibitors of prostaglandin dehydrogenase (Ph CL 28A and Ph CK 61A) increase output of prostaglandins from rat isolated lung.

Authors:  Y S Bakhle; J J Pankhania
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

4.  Effect of dipyridamole on the formation of 6-oxo-prostaglandin F1 alpha by the rat isolated aorta and ram seminal vesicle microsomes.

Authors:  H Bult; A G Herman; V J Van de Velde
Journal:  Br J Pharmacol       Date:  1982-07       Impact factor: 8.739

5.  Studies of the nucleoside transporter inhibitor, draflazine, in the human myocardium.

Authors:  M Böhm; C Weinhold; R H Schwinger; J Müller-Ehmsen; D Böhm; H Reichenspurner; B Reichart; E Erdmann
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

Review 6.  Purine metabolism in the heart. Strategies for protection against myocardial ischaemia.

Authors:  K Ver Donck
Journal:  Pharm World Sci       Date:  1994-04-15

7.  Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.

Authors:  Hyung-Hwan Kim; Naoki Sawada; Guray Soydan; Ho-Seong Lee; Zhipeng Zhou; Seo-Kyoung Hwang; Christian Waeber; Michael A Moskowitz; James K Liao
Journal:  J Cereb Blood Flow Metab       Date:  2008-04-02       Impact factor: 6.200

8.  Effects of the pyrimido-pyrimidine derivative RX-RA 85 on metastatic tumor cell-vascular endothelial cell interactions.

Authors:  R B Lichtner; G L Nicolson
Journal:  Clin Exp Metastasis       Date:  1987-09       Impact factor: 5.150

9.  Chemical sympathectomy abolishes the increase in blood pressure of linoleic acid deficient fed rats induced by salt loading.

Authors:  P Hoffmann; C Taube; K Pönicke; W Förster; L Somova; V Orbetzova; D Kiprov
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-08       Impact factor: 3.000

10.  Attenuation of exercise vasodilatation by adenosine deaminase in anaesthetized dogs.

Authors:  I P Goonewardene; F Karim
Journal:  J Physiol       Date:  1991-10       Impact factor: 5.182
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