Literature DB >> 7044814

Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans.

K Bush, J S Freudenberger, D S Slusarchyk, R B Sykes, E Meyers.   

Abstract

Growth of Candida albicans can be inhibited by sulfa drugs which prevent biosynthesis of folic acid. The dihydrofolate reductase (E.C. 1.5.1.3) inhibitors aminopterin and methotrexate also exhibit anticandidal activity, but trimethoprim does not. Kinetic evaluations with C. albicans dihydrofolate reductase indicate that methotrexate and aminopterin are tight-binding inhibitors whereas trimethoprim binds poorly.

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Year:  1982        PMID： 7044814     DOI： 10.1007/bf01952625

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Differential reversal of inhibitory effects of folic acid analogues on growth, division, and deoxyribonucleic acid synthesis of microorganisms.

Authors:  M WEBB; W J NICKERSON
Journal:  J Bacteriol       Date:  1956-02       Impact factor: 3.490

2.  Inhibitor binding analysis of dihydrofolate reductases from various species.

Authors:  J J Burchall; G H Hitchings
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

Review 3.  Action of imidazole-containing antifungal drugs.

Authors:  W H Beggs; F A Andrews; G A Sarosi
Journal:  Life Sci       Date:  1981-01-12       Impact factor: 5.037

4.  Inhibiton by sulfanilamide of sporulation in Saccharomyces cerevisiae.

Authors:  W J Colonna; J M Gentile; P T Magee
Journal:  Can J Microbiol       Date:  1977-06       Impact factor: 2.419

5.  Potentiation of the antifungal effects of antibiotics by amphotericin B.

Authors:  C N Kwan; G Medoff; G S Kobayashi; D Schlessinger; H J Raskas
Journal:  Antimicrob Agents Chemother       Date:  1972-08       Impact factor: 5.191
  5 in total
  7 in total

1.  A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria.

Authors:  Deborah Mai; Jennifer Jones; John W Rodgers; John L Hartman; Olaf Kutsch; Adrie J C Steyn
Journal:  Assay Drug Dev Technol       Date:  2011-01-31       Impact factor: 1.738

2.  Development of autonomously replicating plasmids for Candida albicans.

Authors:  M B Kurtz; M W Cortelyou; S M Miller; M Lai; D R Kirsch
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

3.  Reversal of Azole Resistance in Candida albicans by Sulfa Antibacterial Drugs.

Authors:  Hassan E Eldesouky; Abdelrahman Mayhoub; Tony R Hazbun; Mohamed N Seleem
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

4.  Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents.

Authors:  Essam M Hussein; Reem I Alsantali; Moataz Morad; Rami J Obaid; Hatem M Altass; Ali Sayqal; Mohamed A S Abourehab; Amal A Elkhawaga; Ahmed S M Aboraia; Saleh A Ahmed
Journal:  BMC Chem       Date:  2020-06-25

5.  Bioactive fluorenes. part I. Synthesis, pharmacological study and molecular docking of novel dihydrofolate reductase inhibitors based-2,7-dichlorofluorene.

Authors:  Essam M Hussein; Reem I Alsantali; Shimaa M Abd El-Galil; Rami J Obaid; Ahmed Alharbi; Mohamed A S Abourehab; Saleh A Ahmed
Journal:  Heliyon       Date:  2019-06-26

6.  Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity.

Authors:  Amani S Awaad; Ahmed M Alafeefy; Fatmah A S Alasmary; Reham M El-Meligy; M E Zain; Saleh I Alqasoumi
Journal:  Saudi Pharm J       Date:  2017-02-27       Impact factor: 4.330

7.  Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors.

Authors:  Essam M Hussein; Munirah M Al-Rooqi; Shimaa M Abd El-Galil; Saleh A Ahmed
Journal:  BMC Chem       Date:  2019-07-11
  7 in total

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