Literature DB >> 7044296

In vivo inhibition of respiratory syncytial virus by ribavirin.

J F Hruska, P E Morrow, S C Suffin, R G Douglas.   

Abstract

Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.

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Year:  1982        PMID： 7044296      PMCID： PMC181839          DOI： 10.1128/AAC.21.1.125

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Efficacy of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide against influenza virus infections in mice.

Authors:  F E Durr; H F Lindh; M Forbes
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

2.  Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice.

Authors:  J S Walker; E L Stephen; R O Spertzel
Journal:  J Infect Dis       Date:  1976-06       Impact factor: 5.226

3.  Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.

Authors:  J T Witkowski; R K Robins; R W Sidwell; L N Simon
Journal:  J Med Chem       Date:  1972-11       Impact factor: 7.446

4.  An evaluation of a new antiviral agent "virazole" against influenza virus infections.

Authors:  T Suganuma; N Ishida
Journal:  Tohoku J Exp Med       Date:  1973-08       Impact factor: 1.848

5.  The pathogenesis of respiratory syncytial virus infection in infant ferrets.

Authors:  G A Prince; D D Porter
Journal:  Am J Pathol       Date:  1976-02       Impact factor: 4.307

6.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

7.  Therapeutic effects of ribavirin given by the intraperitoneal or aerosol route against influenza virus infections in mice.

Authors:  E L Stephen; J W Dominik; J B Moe; J S Walker
Journal:  Antimicrob Agents Chemother       Date:  1976-09       Impact factor: 5.191

8.  In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.

Authors:  J H Huffman; R W Sidwell; G P Khare; J T Witkowski; L B Allen; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191

9.  Treatment of influenza infection of mice by using rimantadine hydrochlorides by the aerosol and intraperitoneal routes.

Authors:  E L Stephen; J W Dominik; J B Moe; R O Spertzel; J S Walker
Journal:  Antimicrob Agents Chemother       Date:  1975-08       Impact factor: 5.191

10.  Suppression by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) of influenza virus-induced infections in mice.

Authors:  G P Khare; R W Sidwell; J T Witkowski; L N Simon; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1973-04       Impact factor: 5.191
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  19 in total

1.  Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.

Authors:  Marie-Eve Hamelin; Gregory A Prince; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 2.  Biochemistry and clinical applications of ribavirin.

Authors:  B E Gilbert; V Knight
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191

Review 3.  Detection, pathogenesis, and therapy of respiratory syncytial virus infections.

Authors:  R C Welliver
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

Review 4.  Respiratory syncytial virus. Brief review.

Authors:  E J Stott; G Taylor
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574

5.  Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane.

Authors:  R R Tidwell; J D Geratz; W A Clyde; K U Rosenthal; E J Dubovi
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191

Review 6.  Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.

Authors:  Peter L Collins; José A Melero
Journal:  Virus Res       Date:  2011-09-22       Impact factor: 3.303

7.  Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice.

Authors:  K Sudo; W Watanabe; K Konno; R Sato; T Kajiyashiki; S Shigeta; T Yokota
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

8.  Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent.

Authors:  J J Kirsi; J A North; P A McKernan; B K Murray; P G Canonico; J W Huggins; P C Srivastava; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1983-09       Impact factor: 5.191

9.  Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro.

Authors:  F Kawana; S Shigeta; M Hosoya; H Suzuki; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1987-08       Impact factor: 5.191

10.  RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy.

Authors:  Rene Alvarez; Sayda Elbashir; Todd Borland; Ivanka Toudjarska; Philipp Hadwiger; Mathias John; Ingo Roehl; Svetlana Shulga Morskaya; Rick Martinello; Jeffrey Kahn; Mark Van Ranst; Ralph A Tripp; John P DeVincenzo; Rajendra Pandey; Martin Maier; Lubomir Nechev; Muthiah Manoharan; Victor Kotelianski; Rachel Meyers
Journal:  Antimicrob Agents Chemother       Date:  2009-06-08       Impact factor: 5.191
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