Literature DB >> 7038679

Enzymatic reduction of oxidized alpha-1-proteinase inhibitor restores biological activity.

W R Abrams, G Weinbaum, L Weissbach, H Weissbach, N Brot.   

Abstract

The major serum inhibitor of proteolytic activity, alpha-1-proteinase inhibitor (alpha-1-PI), (or alpha-1-antitrypsin) can be readily inactivated by oxidation [Carp, H. & Janoff, A. (1978) Am. Rev. Resp. Dis. 118, 617-621]. This inactivation appears to be due to the oxidation of a critical methionine(s) in alpha-1-PI that is required for the inhibition of elastase activity. An enzyme from Escherichia coli that reduces methionine sulfoxide residues in protein [Brot, N., Weissbach, L., Werth, J. & Weissbach, H. (1981) Proc. Natl. Acad. Sci. USA 78, 2155-2158] can restore the biological inhibitory activity of canine oxidized alpha-1-PI.

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Year:  1981        PMID： 7038679      PMCID： PMC349292          DOI： 10.1073/pnas.78.12.7483

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma.

Authors:  A B Cohen
Journal:  Am Rev Respir Dis       Date:  1979-06

2.  Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

Authors:  H Carp; A Janoff
Journal:  Am Rev Respir Dis       Date:  1978-09

3.  Purification and characterization of canine alpha-1-antiproteinase.

Authors:  W R Abrams; P Kimbel; G Weinbaum
Journal:  Biochemistry       Date:  1978-08-22       Impact factor: 3.162

4.  Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro.

Authors:  A Janoff; H Carp
Journal:  Am Rev Respir Dis       Date:  1977-07

5.  The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.

Authors:  D Johnson; J Travis
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157

6.  The dual nature of the reaction between porcine elastase and human plasma alpha1 proteinase inhibitor.

Authors:  S Satoh; T Kurecki; L F Kress; M Laskowski
Journal:  Biochem Biophys Res Commun       Date:  1979-01-15       Impact factor: 3.575

7.  The synthesis and analytical use of a highly sensitive and convenient substrate of elastase.

Authors:  J Bieth; B Spiess; C G Wermuth
Journal:  Biochem Med       Date:  1974-12

8.  Oxidative changes in human lens proteins during senile nuclear cataract formation.

Authors:  R J Truscott; R C Augusteyn
Journal:  Biochim Biophys Acta       Date:  1977-05-27

9.  Human alpha-1-antichymotrypsin: purification and properties.

Authors:  J Travis; D Garner; J Bowen
Journal:  Biochemistry       Date:  1978-12-26       Impact factor: 3.162

10.  Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

Authors:  D Johnson; J Travis
Journal:  J Biol Chem       Date:  1978-10-25       Impact factor: 5.157
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  27 in total

1.  Differential regulation of plastidial and cytosolic isoforms of peptide methionine sulfoxide reductase in Arabidopsis.

Authors:  A Sadanandom; Z Poghosyan; D J Fairbairn; D J Murphy
Journal:  Plant Physiol       Date:  2000-05       Impact factor: 8.340

2.  Bacterial peptide methionine sulphoxide reductase: co-induction with glutathione S-transferase during chemical stress conditions.

Authors:  A Tamburro; N Allocati; M Masulli; D Rotilio; C Di Ilio; B Favaloro
Journal:  Biochem J       Date:  2001-12-15       Impact factor: 3.857

3.  Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells.

Authors:  Chi Zhang; Pingping Jia; Yuanyuan Jia; Yuejin Li; Keith A Webster; Xupei Huang; Mohan Achary; Sharon L Lemanski; Larry F Lemanski
Journal:  J Cell Biochem       Date:  2011-01       Impact factor: 4.429

4.  The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi.

Authors:  M E Hassouni; J P Chambost; D Expert; F Van Gijsegem; F Barras
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205

5.  Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1.

Authors:  Xiao-Xiao Ma; Peng-Chao Guo; Wei-Wei Shi; Ming Luo; Xiao-Feng Tan; Yuxing Chen; Cong-Zhao Zhou
Journal:  J Biol Chem       Date:  2011-02-23       Impact factor: 5.157

6.  Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.

Authors:  J Moskovitz; N A Jenkins; D J Gilbert; N G Copeland; F Jursky; H Weissbach; N Brot
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

7.  A new method of measuring protein-methionine-s-oxide reductase activity.

Authors:  D L Ferguson; J J Burke
Journal:  Plant Physiol       Date:  1992-09       Impact factor: 8.340

8.  E. coli methionine sulfoxide reductase with a truncated N terminus or C terminus, or both, retains the ability to reduce methionine sulfoxide.

Authors:  S Boschi-Muller; S Azza; G Branlant
Journal:  Protein Sci       Date:  2001-11       Impact factor: 6.725

9.  Characterization of the methionine sulfoxide reductases of Schistosoma mansoni.

Authors:  Tolulope T Oke; Jackob Moskovitz; David L Williams
Journal:  J Parasitol       Date:  2009-12       Impact factor: 1.276

Review 10.  Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations.

Authors:  Lisa A Brennan; Marc Kantorow
Journal:  Exp Eye Res       Date:  2008-06-07       Impact factor: 3.467
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