Literature DB >> 7027261

Localization of the human insulin gene to the distal end of the short arm of chromosome 11.

M E Harper, A Ullrich, G F Saunders.   

Abstract

The human insulin gene was mapped by hybridization in situ of 3H-labeled recombinant plasmid pHIG900 to chromosome preparations in the presence of 10% dextran sulfate. pHIG900 contains a 900-base pair insert of human genomic DNA that includes the coding region for the C peptide and intervening sequence 2. A significant percentage of hybridized cells (34%) exhibited silver grains on the distal end of the short arm (band p15) of chromosome 11. Furthermore, silver grains on this region represented 26% of all chromosomal label. These results demonstrate chromosomal localization of the human insulin gene to 11p15.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7027261      PMCID： PMC319810          DOI： 10.1073/pnas.78.7.4458

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Preparation of pancreatic mRNA: cell-free translation of an insulin-immunoreactive polypeptide.

Authors:  P T Lomedico; G F Saunders
Journal:  Nucleic Acids Res       Date:  1976-02       Impact factor: 16.971

2.  A high resolution in situ hybridization technique for the direct visualization of labeled G-banded early metaphase and prophase chromosomes.

Authors:  M E Chandler; J J Yunis
Journal:  Cytogenet Cell Genet       Date:  1978

Review 3.  Current views on the etiology of insulin-dependent diabetes mellitus.

Authors:  J E Craighead
Journal:  N Engl J Med       Date:  1978-12-28       Impact factor: 91.245

Review 4.  Proteolytic processing in the biosynthesis of insulin and other proteins.

Authors:  D F Steiner; W Kemmler; H S Tager; J D Peterson
Journal:  Fed Proc       Date:  1974-10

5.  Characterization of banding patterns of metaphase-prophase G-banded chromosomes and their use in gene mapping.

Authors:  J J Yunis; J R Sawyer; D W Ball
Journal:  Cytogenet Cell Genet       Date:  1978

6.  Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination.

Authors:  S J Chan; P Keim; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

7.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

8.  Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex.

Authors:  L Katz; D T Kingsbury; D R Helinski
Journal:  J Bacteriol       Date:  1973-05       Impact factor: 3.490

Review 9.  Proinsulin and the biosynthesis of insulin.

Authors:  D F Steiner
Journal:  N Engl J Med       Date:  1969-05-15       Impact factor: 91.245

10.  The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene.

Authors:  E C Lai; S L Woo; A Dugaiczyk; B W O'Malley
Journal:  Cell       Date:  1979-01       Impact factor: 41.582
View more
  89 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Delineation of the t complex on mouse chromosome 17 by in situ hybridization.

Authors:  R E Mancoll; L C Snyder; L M Silver
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  A one-step efficient and specific non-radioactive non-fluorescent method for in situ hybridization of banded chromosomes.

Authors:  F R Zhang; R Heilig; G Thomas; A Aurias
Journal:  Chromosoma       Date:  1990-10       Impact factor: 4.316

Review 4.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

5.  Labeling of the centromeric region on human chromosome 8 by in situ hybridization.

Authors:  H U Weier; H D Kleine; J W Gray
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

6.  Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome.

Authors:  S Mita; B Schmidt; E A Schon; S DiMauro; E Bonilla
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

7.  Base sequence of a cloned snake W-chromosome DNA fragment and identification of a male-specific putative mRNA in the mouse.

Authors:  J T Epplen; J R McCarrey; S Sutou; S Ohno
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

8.  Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

Authors:  N Kanda; R Schreck; F Alt; G Bruns; D Baltimore; S Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

9.  Normal dosage of the insulin and insulin-like growth factor II genes in patients with the Beckwith-Wiedemann syndrome.

Authors:  R A Spritz; D Mager; R M Pauli; R Laxova
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

10.  No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population.

Authors:  Yuping Xu; Zhaolian Wei; Zhiguo Zhang; Qiong Xing; Pin Hu; Xiaohui Zhang; Guihua Gao; Yong Wang; Qian Gao; Long Yi; Yunxia Cao
Journal:  Reprod Biol Endocrinol       Date:  2009-12-01       Impact factor: 5.211
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.