Literature DB >> 7017928

Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex.

O H Viveros, C L Lee, M M Abou-Donia, J C Nixon, C A Nichol.   

Abstract

Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide presents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.

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Year:  1981        PMID： 7017928     DOI： 10.1126/science.7017928

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  19 in total

1.  Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.

Authors:  G S Feng; W Dai; S L Gupta; G Werner-Felmayer; H Wachter; O Takikawa; M W Taylor
Journal:  Mol Gen Genet       Date:  1991-11

2.  Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

Authors:  E R Werner; G Werner-Felmayer; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

3.  Isolation of a dihydrofolate reductase-deficient mutant of Escherichia coli.

Authors:  S Singer; R Ferone; L Walton; L Elwell
Journal:  J Bacteriol       Date:  1985-10       Impact factor: 3.490

4.  Biomolecular information analysis in neurotransmitter systems.

Authors:  S C Brooks
Journal:  Acta Biotheor       Date:  1984       Impact factor: 1.774

5.  Guanosine triphosphate cyclohydrolase activity in rat tissues.

Authors:  Z Bellahsene; J L Dhondt; J P Farriaux
Journal:  Biochem J       Date:  1984-01-01       Impact factor: 3.857

6.  Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina.

Authors:  Hongchao Wang; Bo Yang; Guangfei Hao; Yun Feng; Haiqin Chen; Lu Feng; Jianxin Zhao; Hao Zhang; Yong Q Chen; Lei Wang; Wei Chen
Journal:  Microbiology (Reading)       Date:  2011-08-18       Impact factor: 2.777

7.  Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.

Authors:  C A Nichol; C L Lee; M P Edelstein; J Y Chao; D S Duch
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

8.  GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.

Authors:  Aimin He; John P N Rosazza
Journal:  Appl Environ Microbiol       Date:  2003-12       Impact factor: 4.792

9.  Familial glucocorticoid deficiency with achalasia of the cardia associated with mixed neuropathy, long-tract degeneration and mild dementia.

Authors:  D B Grant; D B Dunger; I Smith; K Hyland
Journal:  Eur J Pediatr       Date:  1992-02       Impact factor: 3.183

10.  GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia.

Authors:  A Niederwieser; N Blau; M Wang; P Joller; M Atarés; J Cardesa-Garcia
Journal:  Eur J Pediatr       Date:  1984-02       Impact factor: 3.183
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