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Literature DB >> 2511835

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

E R Werner¹, G Werner-Felmayer, D Fuchs, A Hausen, G Reibnegger, H Wachter.

Abstract

In all of eight tested human cells and cell lines with inducible indoleamine 2,3-dioxygenase (EC 1.13.11.17) tetrahydrobiopterin biosynthesis was activated by interferon-gamma. This was demonstrated by GTP cyclohydrolase I (EC 3.5.4.16) activities and intracellular neopterin and biopterin concentrations. Pteridine synthesis was influenced by extracellular tryptophan. In T 24-cell extracts, submillimolar concentrations of tetrahydrobiopterin stimulated the indoleamine 2,3-dioxygenase reaction.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2511835 PMCID： PMC1133353 DOI： 10.1042/bj2620861

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

32 in total

1. Utilization of dihydroflavin mononucleotide and superoxide anion for the decyclization of L-tryptophan by murine epididymal indoleamine 2,3-dioxygenase.

Authors: Y Ozaki; C A Nichol; D S Duch
Journal: Arch Biochem Biophys Date: 1987-08-15 Impact factor: 4.013

2. Simultaneous determination of neopterin and creatinine in serum with solid-phase extraction and on-line elution liquid chromatography.

Authors: E R Werner; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal: Clin Chem Date: 1987-11 Impact factor: 8.327

Review 3. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Authors: C A Nichol; G K Smith; D S Duch
Journal: Annu Rev Biochem Date: 1985 Impact factor: 23.643

4. Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

Authors: L M de la Maza; E M Peterson
Journal: Cancer Res Date: 1988-01-15 Impact factor: 12.701

5. Inhibition of GTP cyclohydrolase I by pterins.

Authors: R S Shen; A Alam; Y X Zhang
Journal: Biochim Biophys Acta Date: 1988-04-14

6. Human macrophages degrade tryptophan upon induction by interferon-gamma.

Authors: E R Werner; G Bitterlich; D Fuchs; A Hausen; G Reibnegger; G Szabo; M P Dierich; H Wachter
Journal: Life Sci Date: 1987-07-20 Impact factor: 5.037

7. Influence of interferon-gamma and extracellular tryptophan on indoleamine 2,3-dioxygenase activity in T24 cells as determined by a non-radiometric assay.

Authors: E R Werner; G Werner-Felmayer; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal: Biochem J Date: 1988-12-01 Impact factor: 3.857

8. Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase.

Authors: Y Ozaki; J F Reinhard; C A Nichol
Journal: Biochem Biophys Res Commun Date: 1986-06-30 Impact factor: 3.575

9. Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Authors: Y Ozaki; M P Edelstein; D S Duch
Journal: Proc Natl Acad Sci U S A Date: 1988-02 Impact factor: 11.205

10. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

Authors: O Takikawa; T Kuroiwa; F Yamazaki; R Kido
Journal: J Biol Chem Date: 1988-02-05 Impact factor: 5.157

44 in total

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Authors: Luke A J O'Neill; Rigel J Kishton; Jeff Rathmell
Journal: Nat Rev Immunol Date: 2016-07-11 Impact factor: 53.106

2. Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer.

Authors: Ayse Basak Engin; Bensu Karahalil; Ali Esat Karakaya; Atilla Engin
Journal: World J Gastroenterol Date: 2015-03-28 Impact factor: 5.742

3. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.

Authors: Atilla Engin; Ipek Isik Gonul; Ayse Basak Engin; Ahmet Karamercan; Aylin Sepici Dincel; Ayse Dursun
Journal: World J Gastroenterol Date: 2016-04-07 Impact factor: 5.742

4. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

Authors: P Rosenkranz-Weiss; W C Sessa; S Milstien; S Kaufman; C A Watson; J S Pober
Journal: J Clin Invest Date: 1994-05 Impact factor: 14.808

Review 5. Immunopathology of tuberculosis: roles of macrophages and monocytes.

Authors: M J Fenton; M W Vermeulen
Journal: Infect Immun Date: 1996-03 Impact factor: 3.441

6. Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.

Authors: G S Feng; W Dai; S L Gupta; G Werner-Felmayer; H Wachter; O Takikawa; M W Taylor
Journal: Mol Gen Genet Date: 1991-11

7. Immune-mediated mechanisms in multiple sclerosis.

Authors: D Fuchs; G Reibnegger; E R Werner; H Wachter
Journal: J Neurol Date: 1990-04 Impact factor: 4.849

8. In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4⁺ T Lymphocytes.

Authors: Poojitha Matta; Stacy D Sherrod; Christina C Marasco; Daniel J Moore; John A McLean; Joern-Hendrik Weitkamp
Journal: J Immunol Date: 2017-09-25 Impact factor: 5.422

9. Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase.

Authors: J Fleckner; H H Rasmussen; J Justesen
Journal: Proc Natl Acad Sci U S A Date: 1991-12-15 Impact factor: 11.205

10. In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors.

Authors: M Jenny; M Klieber; D Zaknun; S Schroecksnadel; K Kurz; M Ledochowski; H Schennach; Dietmar Fuchs
Journal: Inflamm Res Date: 2010-08-26 Impact factor: 4.575