Literature DB >> 7013400

In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies.

R Bansal, N Ahmad, J R Kidwai.   

Abstract

Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of 14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited the above conversion.

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Year:  1980        PMID： 7013400     DOI： 10.1007/bf02581326

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  25 in total

1.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

2.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

3.  CATHEPTIC DEGRADATION OF BRADYKININ.

Authors:  L M GREENBAUM; K YAMAFUJI
Journal:  Life Sci (1962)       Date:  1965-03

4.  Persisting enhanced proinsulin-insulin and protein biosynthesis (3H-leucine incorporation) by pancreatic islets of the rat after glucose exposure.

Authors:  P Zucker; J Logothetopoulos
Journal:  Diabetes       Date:  1975-02       Impact factor: 9.461

5.  Regulation of rabbit liver fructose-1,6-diphosphatase. II. Modification by lysosomal cathepsin B1 from the same cell.

Authors:  K Nakashima; K Ogino
Journal:  J Biochem       Date:  1974-02       Impact factor: 3.387

6.  Purification and characterization of rat liver lysosomal cathepsin B2.

Authors:  V Ninjoor; S L Taylor; A L Tappel
Journal:  Biochim Biophys Acta       Date:  1974-11-25

7.  Cathepsins D, A and B, and the effect of pH in the pathway of protein hydrolysis.

Authors:  W Goettlich-Riemann; J O Young; A L Tappel
Journal:  Biochim Biophys Acta       Date:  1971-07-25

8.  In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide.

Authors:  R B Puri; K Anjaneyulu; J R Kidwai; V K Mohan Rao
Journal:  Acta Diabetol Lat       Date:  1978 Sep-Dec

9.  THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.

Authors:  M L Anson
Journal:  J Gen Physiol       Date:  1938-09-20       Impact factor: 4.086

10.  Intermediate cells of the pancreas. 3. Selective autophagy and destruction of beta-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocin.

Authors:  R N Melmed; C J Benitez; S J Holt
Journal:  J Cell Sci       Date:  1973-07       Impact factor: 5.285
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  2 in total

1.  Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease.

Authors:  Khyati Mittal; Ruchi Jakhmola Mani; Deepshikha Pande Katare
Journal:  Sci Rep       Date:  2016-05-06       Impact factor: 4.379

2.  Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.

Authors:  T Ohta; T Terada; T Nagakawa; H Tajima; H Itoh; L Fonseca; I Miyazaki
Journal:  Br J Cancer       Date:  1994-01       Impact factor: 7.640
  2 in total

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