| Literature DB >> 7005520 |
L H Block, W Siegenthaler, J Drews.
Abstract
The new antilymphocytic agent Cyclosporin A was found to inhibit the production and/or secretion of migration inhibitory factor (MIF) in human lymphocytes stimulated by Concanavalin A. Preincubation for one hour with the compound, followed by 8 hr restoration period of the cells in absence of the drug, resulted in moderate decrease in MIF synthesis and/or release. Cell viability was not affected. The agent was shown not to interfere with MIF action on the macrophage. We conclude that the molecular mechanism of action of Cyclosporin A is based, at least partially, on a blockade of synthesis and/or secretion of lymphokines from immunocompetent cells.Entities:
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Year: 1980 PMID： 7005520 DOI： 10.1007/bf01478462
Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173