Literature DB >> 7000171

Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.

L M Collum, A Benedict-Smith, I B Hillary.   

Abstract

The results of a randomised double-blind clinical trial of 3% acyclovir and 0.5% idoxuridine (IDU) ophthalmic ointments in 60 patients with corneal dendritic ulceration are presented. Ulcers in all 30 patients treated with acyclovir healed compared with 22 (76%) of 29 patients treated with IDU (P < 0.01). Patients treated with acyclovir healed more rapidly (average 4.4 days) than those who received IDU (average 9.2 days) (P < 0.01). No serious side effects were observed, though transient stinging was recorded in 8 patients receiving acyclovir and in 2 patients receiving IDU. Other side effects in the IDU treated group were watering in 2 patients and superficial punctate erosions in 6 patients.

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Year:  1980        PMID： 7000171      PMCID： PMC1043813          DOI： 10.1136/bjo.64.10.766

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  16 in total

1.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

2.  9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

Authors:  H J Schaeffer; L Beauchamp; P de Miranda; G B Elion; D J Bauer; P Collins
Journal:  Nature       Date:  1978-04-13       Impact factor: 49.962

3.  Acyclovir for treatment of mucocutaneous herpes infection in a child with leukaemia.

Authors:  A O'Meara; P F Deasy; I B Hillary; W D Bridgen
Journal:  Lancet       Date:  1979-12-01       Impact factor: 79.321

4.  Acyclic antimetabolite therapy of experimental herpes simplex keratitis.

Authors:  D Pavan-Langston; R Campbell; J Lass
Journal:  Am J Ophthalmol       Date:  1978-11       Impact factor: 5.258

5.  Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.

Authors:  P C Wellings; P N Awdry; F H Bors; B R Jones; D C Brown; H E Kaufman
Journal:  Am J Ophthalmol       Date:  1972-06       Impact factor: 5.258

6.  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis.

Authors:  D Pavan-Langston; C H Dohlman
Journal:  Am J Ophthalmol       Date:  1972-07       Impact factor: 5.258

7.  The management of ocular herpes.

Authors:  A Patterson; B R Jones
Journal:  Trans Ophthalmol Soc U K       Date:  1967

8.  Double--blind clinical trial of adenine arabinoside and idoxuridine in herpetic corneal ulcers.

Authors:  R H Markham; C Carter; M A Scobie; C Metcalf; D L Easty
Journal:  Trans Ophthalmol Soc U K       Date:  1977-07

9.  Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers.

Authors:  B R Jones; D J Coster; P N Fison; G M Thompson; L M Cobo; M G Falcon
Journal:  Lancet       Date:  1979-02-03       Impact factor: 79.321

10.  Treatment of herpetic keratitis.

Authors:  J Blake; M Browne
Journal:  Doc Ophthalmol       Date:  1977-09-30       Impact factor: 2.379
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  31 in total

1.  Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty.

Authors:  B C Branco; P A Gaudio; T P Margolis
Journal:  Br J Ophthalmol       Date:  2004-10       Impact factor: 4.638

2.  Clinical evaluation of carbocyclic oxetanocin G eyedrops in the treatment of herpes simplex corneal ulcers.

Authors:  H Shiota; K Nitta; T Naito; Y Mimura; T Maruyama
Journal:  Br J Ophthalmol       Date:  1996-05       Impact factor: 4.638

Review 3.  Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors:  Kirk R Wilhelmus
Journal:  Cochrane Database Syst Rev       Date:  2015-01-09

Review 4.  Herpes simplex virus ocular infections: current concepts of acute, latent and reactivated disease.

Authors:  D Pavan-Langston
Journal:  Trans Am Ophthalmol Soc       Date:  1990

5.  A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration.

Authors:  B J Young; A Patterson; T Ravenscroft
Journal:  Br J Ophthalmol       Date:  1982-06       Impact factor: 4.638

6.  Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.

Authors:  H B Hoh; C Hurley; C Claoue; M Viswalingham; D L Easty; P Goldschmidt; L M Collum
Journal:  Br J Ophthalmol       Date:  1996-02       Impact factor: 4.638

7.  Oral acyclovir in the management of dendritic herpetic corneal ulceration.

Authors:  S O Hung; A Patterson; D I Clark; P J Rees
Journal:  Br J Ophthalmol       Date:  1984-06       Impact factor: 4.638

8.  Oral acyclovir (Zovirax) in herpes simplex dendritic corneal ulceration.

Authors:  L M Collum; P McGettrick; J Akhtar; J Lavin; P J Rees
Journal:  Br J Ophthalmol       Date:  1986-06       Impact factor: 4.638

9.  Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes.

Authors:  Joseph Colin
Journal:  Clin Ophthalmol       Date:  2007-12

10.  Pharmacokinetics of oral acyclovir (Zovirax) in the eye.

Authors:  S O Hung; A Patterson; P J Rees
Journal:  Br J Ophthalmol       Date:  1984-03       Impact factor: 4.638
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