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Literature DB >> 6696872

Pharmacokinetics of oral acyclovir (Zovirax) in the eye.

Abstract

Patients due for cataract extraction received 5 doses of 400 mg acyclovir (Zovirax) orally during the 24 hours prior to surgery. Aqueous humour levels of acyclovir (mean 3.26 microM) were well above the normal ED50 range for herpes simplex virus type 1, and showed a significant correlation with plasma concentrations (mean 8.74 microM). There was also a correlation between the age of the patient and the concentration of acyclovir in the plasma. Oral acyclovir was well tolerated.

Entities: Chemical Disease Species

Mesh：

Substances：
Acyclovir

Year: 1984 PMID： 6696872 PMCID： PMC1040285 DOI： 10.1136/bjo.68.3.192

Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638

23 in total

1. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors: G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

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Authors: H J Schaeffer; L Beauchamp; P de Miranda; G B Elion; D J Bauer; P Collins
Journal: Nature Date: 1978-04-13 Impact factor: 49.962

3. Herpetic iritis: demonstration of virus in the anterior chamber by fluorescent antibody techniques and electron microscopy.

Authors: H E Kaufman; A Kanai; E D Ellison
Journal: Am J Ophthalmol Date: 1971-02 Impact factor: 5.258

4. Symposium on certain forms of infective kerato-uveitis or uveitis. I. An approach to the problem, and the technique of anterior chamber tap.

Authors: B R Jones; A Patterson; N S Rice
Journal: Trans Ophthalmol Soc U K Date: 1969

5. Electron microscope observation of herpes-like particles in the iris.

Authors: R Witmer; T Iwamoto
Journal: Arch Ophthalmol Date: 1968-03

6. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.

Authors: E De Clercq; J Descamps; G Verhelst; R T Walker; A S Jones; P F Torrence; D Shugar
Journal: J Infect Dis Date: 1980-05 Impact factor: 5.226

7. Growth inhibition by acycloguanosine of herpesviruses isolated from human infections.

Authors: C S Crumpacker; L E Schnipper; J A Zaia; M J Levin
Journal: Antimicrob Agents Chemother Date: 1979-05 Impact factor: 5.191

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Authors: R P Quinn; P de Miranda; L Gerald; S S Good
Journal: Anal Biochem Date: 1979-10-01 Impact factor: 3.365

9. Acyclovir and idoxiuridine treatment of herpes simplex keratitis--a double blind clinical study.

Authors: A Klauber; E Ottovay
Journal: Acta Ophthalmol (Copenh) Date: 1982-10

10. Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers.

Authors: B R Jones; D J Coster; P N Fison; G M Thompson; L M Cobo; M G Falcon
Journal: Lancet Date: 1979-02-03 Impact factor: 79.321

17 in total

1. A comparison of local and systemic acyclovir in the management of herpetic disciform keratitis.

Authors: S M Porter; A Patterson; P Kho
Journal: Br J Ophthalmol Date: 1990-05 Impact factor: 4.638

Review 2. Ocular surgery after herpes simplex and herpes zoster keratitis.

Authors: Piotr Kanclerz; Jorge L Alio
Journal: Int Ophthalmol Date: 2020-09-10 Impact factor: 2.031

Review 3. Update on Herpes simplex keratitis management.

Authors: Daniel Sibley; Daniel F P Larkin
Journal: Eye (Lond) Date: 2020-08-25 Impact factor: 3.775

4. The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin.

Authors: M Halberstadt; M Machens; K-A Gahlenbek; M Böhnke; J G Garweg
Journal: Br J Ophthalmol Date: 2002-06 Impact factor: 4.638

5. Self-Retained Amniotic Membrane Combined With Antiviral Therapy for Herpetic Epithelial Keratitis.

Authors: Anny M S Cheng; Scheffer C G Tseng
Journal: Cornea Date: 2017-11 Impact factor: 2.651

6. Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group.

Authors: K R Wilhelmus; C R Dawson; B A Barron; P Bacchetti; L Gee; D B Jones; H E Kaufman; J Sugar; R A Hyndiuk; P R Laibson; R D Stulting; P A Asbell
Journal: Br J Ophthalmol Date: 1996-11 Impact factor: 4.638