Literature DB >> 6997288

On the mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C--H bond cleavage.

J Stubbe, D Ackles.   

Abstract

The 3'-carbon--hydrogen bond of [3'-3H]uridine 5'-diphosphate is cleaved during its conversion to 2'-deoxyuridine 5'-diphosphate catalyzed by Esherichia coli ribonucleoside diphosphate reductase. A selection against 3H of approximately 3.3 is observed on this reduction reaction. During the course of this reaction, a small but significant amount of 3H is released to the solvent.

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Year:  1980        PMID： 6997288

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  21 in total

1.  High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase.

Authors:  C C Lawrence; M Bennati; H V Obias; G Bar; R G Griffin; J Stubbe
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Charge-Transfer Dynamics at the α/β Subunit Interface of a Photochemical Ribonucleotide Reductase.

Authors:  Lisa Olshansky; JoAnne Stubbe; Daniel G Nocera
Journal:  J Am Chem Soc       Date:  2016-01-21       Impact factor: 15.419

3.  Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase.

Authors:  Clorice R Reinhardt; Pengfei Li; Gyunghoon Kang; JoAnne Stubbe; Catherine L Drennan; Sharon Hammes-Schiffer
Journal:  J Am Chem Soc       Date:  2020-07-28       Impact factor: 15.419

4.  Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.

Authors:  Bradley M Hover; Anna Loksztejn; Anthony A Ribeiro; Kenichi Yokoyama
Journal:  J Am Chem Soc       Date:  2013-04-29       Impact factor: 15.419

5.  The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant.

Authors:  Yifeng Wei; Michael A Funk; Leonardo A Rosado; Jiyeon Baek; Catherine L Drennan; JoAnne Stubbe
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-25       Impact factor: 11.205

Review 6.  Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.

Authors:  Brandon L Greene; Gyunghoon Kang; Chang Cui; Marina Bennati; Daniel G Nocera; Catherine L Drennan; JoAnne Stubbe
Journal:  Annu Rev Biochem       Date:  2020-06-20       Impact factor: 23.643

7.  Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer.

Authors:  Wei Jiang; Jiajia Xie; Paul T Varano; Carsten Krebs; J Martin Bollinger
Journal:  Biochemistry       Date:  2010-06-29       Impact factor: 3.162

8.  Radical-translocation intermediates and hurdling of pathway defects in "super-oxidized" (Mn(IV)/Fe(IV)) Chlamydia trachomatis ribonucleotide reductase.

Authors:  Laura M K Dassama; Wei Jiang; Paul T Varano; Maria-Eirini Pandelia; Denise A Conner; Jiajia Xie; J Martin Bollinger; Carsten Krebs
Journal:  J Am Chem Soc       Date:  2012-12-04       Impact factor: 15.419

9.  Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer.

Authors:  Bigna Wörsdörfer; Denise A Conner; Kenichi Yokoyama; Jovan Livada; Mohammad Seyedsayamdost; Wei Jiang; Alexey Silakov; JoAnne Stubbe; J Martin Bollinger; Carsten Krebs
Journal:  J Am Chem Soc       Date:  2013-05-31       Impact factor: 15.419

10.  Structural basis for assembly of the Mn(IV)/Fe(III) cofactor in the class Ic ribonucleotide reductase from Chlamydia trachomatis.

Authors:  Laura M K Dassama; Carsten Krebs; J Martin Bollinger; Amy C Rosenzweig; Amie K Boal
Journal:  Biochemistry       Date:  2013-09-03       Impact factor: 3.162
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