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Literature DB >> 6987167

Immunogenicity of the ribosomal fraction of Salmonella typhimurium: analysis of humoral immunity.

Abstract

The ribosomal fraction prepared from Salmonella typhimurium LT2 was further purified by gel filtration of Sepharose 4B and afforded excellent protection against homologous challenge. The highly effective immunogens were composed of several fractions which could give different types of protection to mice. The first type of protection was heat-labile antigens which could induce humoral immunity, and the second type of protection was heat-stable antigens capable of evoking cellular resistance in mice. The former were different from O-antigens and the latter were free of endotoxin and rich in ribonucleic acid. The third type of protection was heat-resistant substances of cell wall components, which were mainly composed of O-antigens. The high immunogenicity observed in this study could be obtained only by the heat-stable antigens rich in ribonucleic acid, and the immunity conferred by this kind of antigen was due to the cellular type of protection.

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Year: 1980 PMID： 6987167 PMCID： PMC550744 DOI： 10.1128/iai.27.1.197-203.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

14 in total

1. Evidence for an extrinsic immunogen in effective ribosomal vaccines from Salmonella typhimurium.

Authors: P Hoops; N E Prather; J Berry; J M Ravel
Journal: Infect Immun Date: 1976-04 Impact factor: 3.441

2. The use of strain LT2-Ml in identifying the protective antigens in a Salmonella typhimurium-derived ribosomal vaccine.

Authors: J H Lin; L J Berry
Journal: J Reticuloendothel Soc Date: 1978-02

3. Evidence for O antigens as the antigenic determinants in "ribosomal" vaccines prepared from Salmonella.

Authors: T K Eisenstein
Journal: Infect Immun Date: 1975-08 Impact factor: 3.441

4. Role of endotoxin contamination in ribiosomal vaccines prepared from Salmonella typhimurium.

Authors: M L Misfeldt; W Johnson
Journal: Infect Immun Date: 1977-07 Impact factor: 3.441

5. Effect of nonspecific stimulation on the defense mechanisms of inbred mice.

Authors: S Medina; S I Vas; H G Robson
Journal: J Immunol Date: 1975-06 Impact factor: 5.422

6. Isolation and partial characterization of an immunogenic moiety obtained from Salmonella typhimurium.

Authors: M R Venneman; N J Bigley
Journal: J Bacteriol Date: 1969-10 Impact factor: 3.490

7. Immunogenic mycobacterial ribosomal and ribonucleic Acid preparations: chemical and physical characteristics.

Authors: A S Youmans; G P Youmans
Journal: Infect Immun Date: 1970-11 Impact factor: 3.441

8. Ribosomal vaccines. I. Immunogenicity of ribosomal fractions isolated from Salmonella typhimurium and Yersinia pestis.

Authors: W Johnson
Journal: Infect Immun Date: 1972-06 Impact factor: 3.441

9. Acquired immunity to murine typhoid induced in mice with fractions of Salmonella typhimurium.

Authors: J L Molinari; C Larralde
Journal: Rev Latinoam Microbiol Date: 1974 Oct-Dec

10. Mechanisms of acquired resistance in mouse typhoid.

Authors: R V Blanden; G B Mackaness; F M Collins
Journal: J Exp Med Date: 1966-10-01 Impact factor: 14.307

11 in total

1. Analysis of immunity to infection with Salmonella typhimurium in outbred mice. II. Isolation and immunogenicity of the protective non-O antigenic component from ribosomal vaccine.

Authors: E Kita; M Emoto; N Katsui; K Nishi; K Yasui; K Yasui; S Kashiba
Journal: Immunology Date: 1987-10 Impact factor: 7.397

2. Analysis of immune responses in genital tracts of mice immunised with purified ribosomal fractions of Neisseria gonorrhoeae.

Authors: E Kita; S Kashiba
Journal: Br J Vener Dis Date: 1984-08

3. Detection of antibodies against Candida albicans ribosomes by the enzyme linked immunosorbent assay.

Authors: R Levy; E Segal; E Eylan
Journal: Mycopathologia Date: 1984-09-30 Impact factor: 2.574

4. Artificial Salmonella vaccines: Salmonella typhimurium O-antigen-specific oligosaccharide-protein conjugates elicit protective antibodies in rabbits and mice.

Authors: S B Svenson; A A Lindberg
Journal: Infect Immun Date: 1981-05 Impact factor: 3.441

5. Cellular aspects of the longer-lasting immunity against mouse typhoid infection afforded by the live-cell and ribosomal vaccines.

Authors: E Kita; M Emoto; K Yasui; K Yasui; N Katsui; K Nishi; S Kashiba
Journal: Immunology Date: 1986-03 Impact factor: 7.397

6. Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes.

Authors: R Levy; E Segal; E Eylan; L Barr-Nea
Journal: Mycopathologia Date: 1983-11-25 Impact factor: 2.574

7. Immunogenicity of a low-virulence vaccinal strain against Salmonella abortus-ovis infection in mice.

Authors: F Lantier; P Pardon; J Marly
Journal: Infect Immun Date: 1983-05 Impact factor: 3.441

8. Analysis of immunity to infection with Salmonella typhimurium in outbred mice. I. Requirement of the antibody to non-O antigen for protection in mice that are not protected by the RNA-rich vaccine.

Authors: E Kita; K Nishi; M Emoto; N Katsui; K Yasui; K Yasui; S Kashiba
Journal: Immunology Date: 1987-08 Impact factor: 7.397

9. Passive hemagglutination test for detection of antibody to gonococcal ribosomal antigen in sera from patients with asymptomatic gonorrhea.

Authors: E Kita; S Kashiba
Journal: J Clin Microbiol Date: 1982-04 Impact factor: 5.948

10. A protective role of extrathymic alpha beta TcR cells in the liver in primary murine salmonellosis.

Authors: Y Matsumoto; M Emoto; J Usami; K Maeda; Y Yoshikai
Journal: Immunology Date: 1994-01 Impact factor: 7.397