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Literature DB >> 6366570

Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes.

Abstract

The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.

Entities: Chemical Disease Species

Mesh：

Year: 1983 PMID： 6366570 DOI： 10.1007/bf00437023

Source DB: PubMed Journal: Mycopathologia ISSN： 0301-486X Impact factor: 2.574

19 in total

1. Adoptive transfer of immunity from mice immunized with ribosomes or live yeast cells of Histoplasma capsulatum.

Authors: R P Tewari; D Sharma; M Solotorovsky; R Lafemina; J Balint
Journal: Infect Immun Date: 1977-03 Impact factor: 3.441

2. Humoral immunity to Streptococcus pneumoniae induced by a pneumococcal ribosomal protein fraction.

Authors: C L Swendsen; W Johnson
Journal: Infect Immun Date: 1976-08 Impact factor: 3.441

3. Experimental salmonellosis: differential passive transfer of immunity with serum and cells obtained from ribosomal and ribonucleic acid-immunized mice.

Authors: M R Venneman; L J Berry
Journal: J Reticuloendothel Soc Date: 1971-05

4. Delayed hypersensitivity to ribosomal protein from BCG.

Authors: L Ortiz-Ortiz; E B Solarolo; L F Bojalil
Journal: J Immunol Date: 1971-10 Impact factor: 5.422

5. Passive immunization against Pseudomonas with a ribosomal vaccine-induced immune serum and immunoglobulin fractions.

Authors: M M Lieberman; D C McKissock; G L Wright
Journal: Infect Immun Date: 1979-02 Impact factor: 3.441

6. Effect of systemic candidiasis on blastogenesis of lymphocytes from germfree and conventional rats.

Authors: T J Rogers; E Balish
Journal: Infect Immun Date: 1978-04 Impact factor: 3.441

7. Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs.

Authors: P G Sohnle; M M Frank; C H Kirkpatrick
Journal: J Immunol Date: 1976-08 Impact factor: 5.422

8. Immunization of mice with Trypanosoma cruzi polyribosomes.

Authors: L L Leon; W Leon; L Chaves; S C Costa; M Q Cruz; H M Brascher; A O Lima
Journal: Infect Immun Date: 1980-01 Impact factor: 3.441

9. Protective immunity against murine candidiasis elicited by Candida albicans ribosomal fractions.

Authors: R Levy; E Segal; E Eylan
Journal: Infect Immun Date: 1981-03 Impact factor: 3.441

10. Delayed hypersensitivity reactions provoked by ribosomes from acid-fast bacilli. I. Ribosomal isolation, characterization, delayed hypersensitivity, and specificity.

Authors: R E Baker; W E Hill; C L Larson
Journal: Infect Immun Date: 1972-09 Impact factor: 3.441

3 in total