Literature DB >> 6984651

Interaction of clavulanate with the beta-lactamases of Streptomyces albus G and Actinomadura R39.

J M Frère, C Dormans, V M Lenzini, C Duyckaerts.   

Abstract

The reactions of beta-lactamases of Actinomadura R39 and Streptomyces albus G with clavulanate proceed along branched pathways. Both enzymes perform the hydrolysis of this beta-lactam with rather high efficiencies (kcat. = 18s-1 and 52s-1 respectively). If large clavulanate/enzyme ratios are used, complete inactivation of the enzymes is observed. At lower ratios, inactivation is only partial. Irreversible inactivation occurs after 400 and 20000 turnovers for the A. R39 and S. albus G enzymes respectively. With the A. R39 beta-lactamase, a transiently inhibited complex is also formed that remains undetectable with the S. albus G beta-lactamase. Kinetic models are presented and studied for the interaction between clavulanate and both enzymes. A tentative general reaction scheme is also discussed.

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Year:  1982        PMID： 6984651      PMCID： PMC1153882          DOI： 10.1042/bj2070429

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  A semi-synthetic penicillinase inactivator.

Authors:  S J Cartwright; A F Coulson
Journal:  Nature       Date:  1979-03-22       Impact factor: 49.962

2.  Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.

Authors:  C Reading; M Cole
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

3.  Kinetics of suicide substrates.

Authors:  S G Waley
Journal:  Biochem J       Date:  1980-03-01       Impact factor: 3.857

4.  The inhibition of staphylococcal beta-lactamase by clavulanic acid.

Authors:  C Reading; P Hepburn
Journal:  Biochem J       Date:  1979-04-01       Impact factor: 3.857

5.  The inhibition of beta-lactamases from gram-negative bacteria by clavulanic acid.

Authors:  C Reading; T Farmer
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

6.  Clavulanic acid, a novel inhibitor of beta-lactamases.

Authors:  H C Neu; K P Fu
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

7.  Kinetic studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid.

Authors:  J Fisher; R L Charnas; J R Knowles
Journal:  Biochemistry       Date:  1978-05-30       Impact factor: 3.162

8.  Chemical studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid.

Authors:  R L Charnas; J Fisher; J R Knowles
Journal:  Biochemistry       Date:  1978-05-30       Impact factor: 3.162

9.  [Kinetics of beta-lactamase inhibition by clavulanic acid].

Authors:  R Labia; J Peduzzi
Journal:  Biochim Biophys Acta       Date:  1978-10-12

10.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191
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  21 in total

1.  Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.

Authors:  Thérèse Stachyra; Marie-Claude Péchereau; Jean-Michel Bruneau; Monique Claudon; Jean-Marie Frère; Christine Miossec; Kenneth Coleman; Michael T Black
Journal:  Antimicrob Agents Chemother       Date:  2010-10-04       Impact factor: 5.191

2.  The kinetics of substrate-induced inactivation.

Authors:  S G Waley
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

3.  Kinetic study of interaction between BRL 42715, beta-lactamases, and D-alanyl-D-alanine peptidases.

Authors:  A Matagne; P Ledent; D Monnaie; A Felici; M Jamin; X Raquet; M Galleni; D Klein; I François; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

4.  6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.

Authors:  F De Meester; J M Frère; S G Waley; S J Cartwright; R Virden; F Lindberg
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

5.  Inhibition of class C beta-lactamases by (1'R,6R)-6-(1'-hydroxy)benzylpenicillanic acid SS-dioxide.

Authors:  G C Knight; S G Waley
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

6.  Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.

Authors:  Eric Sauvage; Eveline Fonzé; Birgit Quinting; Moreno Galleni; Jean-Marie Frère; Paulette Charlier
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

7.  A kinetic study of the suicide inactivation of an enzyme measured through coupling reactions. Application to the suicide inactivation of tyrosinase.

Authors:  J Escribano; J Tudela; F Garcia-Carmona; F Garcia-Canovas
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

8.  Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Authors:  Krisztina M Papp-Wallace; Christopher R Bethel; Anne M Distler; Courtney Kasuboski; Magdalena Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

9.  Interaction of beta-iodopenicillanate with the beta-lactamases of Streptomyces albus G and Actinomadura R39.

Authors:  J M Frère; C Dormans; C Duyckaerts; J De Graeve
Journal:  Biochem J       Date:  1982-12-01       Impact factor: 3.857

10.  Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.

Authors:  M Galleni; N Franceschini; B Quinting; L Fattorini; G Orefici; A Oratore; J M Frère; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191
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