Literature DB >> 6299270

Interaction of beta-iodopenicillanate with the beta-lactamases of Streptomyces albus G and Actinomadura R39.

J M Frère, C Dormans, C Duyckaerts, J De Graeve.   

Abstract

The beta-lactamases of Streptomyces albus G and Actinomadura R39 are inactivated by beta-iodopenicillanate. However, in contrast with the beta-lactamase I from Bacillus cereus, they also efficiently catalyse the hydrolysis of the inactivator; with the S. albus G enzyme, kcat. is larger than 25s-1 and the number of turnovers before inactivation is 515. With the A. R39 enzyme, kcat. is larger than 50s-1 and the number of turnovers before inactivation is 80. After hydrolysis of the beta-lactam amide bond, the product rearranges into 2.3-dihydro-2,2-dimethyl-1,4-thiazine-3,6-dicarboxylate, which exhibits an absorption maximum at 305 nm.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6299270      PMCID： PMC1153883          DOI： 10.1042/bj2070437

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Penicillinase active sites: labelling of serine-44 in beta-lactamase I by 6beta-bromopenicillanic acid.

Authors:  V Knott-Hunziker; S G Waley; B S Orlek; P G Sammes
Journal:  FEBS Lett       Date:  1979-03-01       Impact factor: 4.124

2.  A semi-synthetic penicillinase inactivator.

Authors:  S J Cartwright; A F Coulson
Journal:  Nature       Date:  1979-03-22       Impact factor: 49.962

3.  Beta-lactamase inactivation by mechanism-based reagents.

Authors:  J Fisher; J G Belasco; R L Charnas; S Khosla; J R Knowles
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1980-05-16       Impact factor: 6.237

4.  Active site of staphylococcal beta-lactamase.

Authors:  S J Cartwright; A F Coulson
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1980-05-16       Impact factor: 6.237

5.  On the chemistry of beta-lactamase inhibition by 6 beta-bromopenicillanic acid.

Authors:  B S Orlek; P G Sammes; V Knott-Hunziker; S G Waley
Journal:  J Chem Soc Perkin 1       Date:  1980

6.  beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin.

Authors:  J Fisher; J G Belasco; S Khosla; J R Knowles
Journal:  Biochemistry       Date:  1980-06-24       Impact factor: 3.162

7.  Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopenicillanic acid: kinetics.

Authors:  M J Loosemore; S A Cohen; R F Pratt
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162

8.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191

9.  Kinetics of inactivation of beta-lactamase I by 6 beta-bromopenicillanic acid.

Authors:  V Knott-Hunziker; B S Orlek; P G Sammes; S G Waley
Journal:  Biochem J       Date:  1980-06-01       Impact factor: 3.857

10.  Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism.

Authors:  S A Cohen; R F Pratt
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162
View more
  24 in total

1.  The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G.

Authors:  F De Meester; B Joris; M V Lenzini; P Dehottay; T Erpicium; J Dusart; D Klein; J M Ghuysen; J M Frère; J Van Beeumen
Journal:  Biochem J       Date:  1987-06-01       Impact factor: 3.857

2.  The kinetics of substrate-induced inactivation.

Authors:  S G Waley
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

3.  Active-site serine mutants of the Streptomyces albus G beta-lactamase.

Authors:  F Jacob; B Joris; J M Frère
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

4.  Kinetic study of interaction between BRL 42715, beta-lactamases, and D-alanyl-D-alanine peptidases.

Authors:  A Matagne; P Ledent; D Monnaie; A Felici; M Jamin; X Raquet; M Galleni; D Klein; I François; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

5.  6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.

Authors:  F De Meester; J M Frère; S G Waley; S J Cartwright; R Virden; F Lindberg
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

6.  Chromosome-encoded beta-lactamases of Citrobacter diversus. Interaction with beta-iodopenicillanate and labelling of the active site.

Authors:  G Amicosante; A Oratore; B Joris; M Galleni; J M Frère; J Van Beeumen
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

7.  Inhibition by Avibactam and Clavulanate of the β-Lactamases KPC-2 and CTX-M-15 Harboring the Substitution N132G in the Conserved SDN Motif.

Authors:  Clément Ourghanlian; Daria Soroka; Michel Arthur
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

8.  Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Authors:  Krisztina M Papp-Wallace; Christopher R Bethel; Anne M Distler; Courtney Kasuboski; Magdalena Taracila; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

9.  Characterization of the chromosomal cephalosporinases produced by Acinetobacter lwoffii and Acinetobacter baumannii clinical isolates.

Authors:  M Perilli; A Felici; A Oratore; G Cornaglia; G Bonfiglio; G M Rossolini; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

10.  Kinetic analysis of extension of substrate specificity with Xanthomonas maltophilia, Aeromonas hydrophila, and Bacillus cereus metallo-beta-lactamases.

Authors:  A Felici; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.