Literature DB >> 6983886

Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.

P J Tutton, D H Barkla.   

Abstract

Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice.

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Year:  1982        PMID： 6983886      PMCID： PMC2011088          DOI： 10.1038/bjc.1982.191

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  13 in total

1.  The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats.

Authors:  P J Tutton; D H Barkla
Journal:  Clin Exp Pharmacol Physiol       Date:  1978 Jan-Feb       Impact factor: 2.557

Review 2.  Inhibition of serotonin reuptake.

Authors:  R W Fuller; D T Wong
Journal:  Fed Proc       Date:  1977-07

Review 3.  Another look at the monoamine oxidases and the monoamine oxidase inhibitor drugs.

Authors:  N H Neff; H Y Yang
Journal:  Life Sci       Date:  1974-06-01       Impact factor: 5.037

4.  Evaluation of the cytotoxicity of dihydroxytryptamines and 5-hydroxytryptamine antagonists as cytotoxic agents in dimethylhydrazine-induced adenocarcinomata.

Authors:  P J Tutton; D H Barkla
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

5.  Pharmacology of a new phthalane (Lu 10-171), with specific 5-HT uptake inhibiting properties.

Authors:  A V Christensen; B Fjalland; V Pedersen; P Danneskiold-Samsoe; O Svendsen
Journal:  Eur J Pharmacol       Date:  1977-01-21       Impact factor: 4.432

6.  Extrapyramidal side effects and increased serum prolactin following fluoxetine, a new antidepressant.

Authors:  H Y Meltzer; M Young; J Metz; V S Fang; P M Schyve; R C Arora
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

7.  Enhancement of insulin-induced prolactin secretion by fluoxetine in man.

Authors:  A Masala; G Delitala; L Devilla; S Alagna; P P Rovasio
Journal:  J Clin Endocrinol Metab       Date:  1979-09       Impact factor: 5.958

8.  Uptake and release of 5-hydroxytryptamine by enteric 5-hydroxytryptaminergic neurones: effects of fluoxetine (Lilly 110140) and chlorimipramine.

Authors:  M D Gershon; G M Jonakait
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

9.  Effect of a selective 5-HT uptake inhibitor--Lu 10-171--on rat brain 5-HT turnover.

Authors:  J Hyttel
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1977-03

10.  Improved immune-suppression techniques for the exongrafting of human tumours.

Authors:  G G Steel; V D Courtenay; A Y Rostom
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640
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  19 in total

1.  Colorectal cancer risk in relation to antidepressant medication use.

Authors:  Jessica Chubak; Denise M Boudreau; Stephen J Rulyak; Margaret T Mandelson
Journal:  Int J Cancer       Date:  2011-01-01       Impact factor: 7.396

2.  Antidepressant Use and Risk of Colorectal Cancer in the Women's Health Initiative.

Authors:  Jenna F Kiridly-Calderbank; Susan R Sturgeon; Candyce H Kroenke; Katherine W Reeves
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2018-05-22       Impact factor: 4.254

Review 3.  Predictive tests in cancer chemotherapy. A reappraisal.

Authors:  R Osieka; S Seeber; C G Schmidt
Journal:  Klin Wochenschr       Date:  1984-03-01

4.  Use of antidepressants after colon cancer diagnosis and risk of recurrence.

Authors:  Gaia Pocobelli; Onchee Yu; Rebecca A Ziebell; Erin J Aiello Bowles; Monica M Fujii; Andrew T Sterrett; Jennifer M Boggs; Lu Chen; Denise M Boudreau; Debra P Ritzwoller; Rebecca A Hubbard; Jessica Chubak
Journal:  Psychooncology       Date:  2019-02-14       Impact factor: 3.894

Review 5.  Antidepressants and breast and ovarian cancer risk: a review of the literature and researchers' financial associations with industry.

Authors:  Lisa Cosgrove; Ling Shi; David E Creasey; Maria Anaya-McKivergan; Jessica A Myers; Krista F Huybrechts
Journal:  PLoS One       Date:  2011-04-06       Impact factor: 3.240

Review 6.  Antidepressant fluoxetine and its potential against colon tumors.

Authors:  Helga Stopper; Sergio Britto Garcia; Ana Maria Waaga-Gasser; Vinicius Kannen
Journal:  World J Gastrointest Oncol       Date:  2014-01-15

7.  Antidepressant use and colorectal cancer risk.

Authors:  Patricia F Coogan; Brian L Strom; Lynn Rosenberg
Journal:  Pharmacoepidemiol Drug Saf       Date:  2009-11       Impact factor: 2.890

8.  Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation.

Authors:  Masanori Asada; Satoru Ebihara; Shinsuke Yamanda; Kaijun Niu; Tatsuma Okazaki; Ichiro Sora; Hiroyuki Arai
Journal:  Neoplasia       Date:  2009-04       Impact factor: 5.715

9.  Antidepressant use and colorectal cancer risk: a Danish population-based case-control study.

Authors:  D P Cronin-Fenton; A H Riis; T L Lash; S O Dalton; S Friis; D Robertson; H T Sørensen
Journal:  Br J Cancer       Date:  2010-09-28       Impact factor: 7.640

10.  Antiproliferative effects of fluoxetine on colon cancer cells and in a colonic carcinogen mouse model.

Authors:  Vinicius Kannen; Henning Hintzsche; Dalila L Zanette; Wilson A Silva; Sérgio B Garcia; Ana Maria Waaga-Gasser; Helga Stopper
Journal:  PLoS One       Date:  2012-11-27       Impact factor: 3.240
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