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Literature DB >> 313230

Uptake and release of 5-hydroxytryptamine by enteric 5-hydroxytryptaminergic neurones: effects of fluoxetine (Lilly 110140) and chlorimipramine.

Abstract

The effect of fluoxetine on uptake of 5-hydroxytryptamine (5-HT) by enteric 5-hydroxytryptaminergic neurones has been analyzed in order to compare further these neurones with 5-HT neurones of the CNS. In addition, the effects of fluoxetine and chlorimipramine on efflux of [3H]-5-HT from the myenteric plexus were also evaluated. Fluoxetine was found to be a competitive inhibitor of 5-HT uptake by the myenteric plexus and was a more potent inhibitor of 5-HT uptake than was chlorimipramine. However, chlorimipramine enhanced the efflux of [3H]-5-HT more than could be explained by inhibition of 5-HT uptake and, therefore, appears to have the additional action of releasing the amine. These observations, similar to those of others studying central neurones, support the view that enteric 5-HT neurones resemble those of the CNS and are a useful model for the evaluation of drugs.

Entities: Chemical

Mesh：

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Year: 1979 PMID： 313230 PMCID： PMC2043830 DOI： 10.1111/j.1476-5381.1979.tb16089.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

8 in total

1. Serotonergic neurons in the peripheral nervous system: identification in gut by immunohistochemical localization of tryptophan hydroxylase.

Authors: M D Gershon; C F Dreyfus; V M Pickel; T H Joh; D J Reis
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

2. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.

Authors: D T Wong; J S Horng; F P Bymaster; K L Hauser; B B Molloy
Journal: Life Sci Date: 1974-08-01 Impact factor: 5.037

3. An analysis of the uptake of 5-hydroxytryptamine by the myenteric plexus of the small intestine of the guinea pig.

Authors: M D Gershon; R F Altman
Journal: J Pharmacol Exp Ther Date: 1971-10 Impact factor: 4.030

4. Detection of a soluble serotonin-binding protein in the mammalian myenteric plexus and other peripheral sites of serotonin storage.

Authors: G M Jonakait; H Tamir; M M Rapport; M D Gershon
Journal: J Neurochem Date: 1977-02 Impact factor: 5.372

5. Regulation of (3H)5-hydroxytryptamine release from rat brain slices.

Authors: L O Farnebo; B Hamberger
Journal: J Pharm Pharmacol Date: 1974-08 Impact factor: 3.765

6. Release of transmitters into the perfused third cerebral ventrical of the cat.

Authors: R Ashkenazi; R B Holman; M Vogt
Journal: J Physiol Date: 1973-08 Impact factor: 5.182

7. Serotonin accumulation in the guinea-pig myenteric plexus: ion dependence, structure-activity relationship and the effect of drugs.

Authors: M D Gershon; R G Robinson; L L Ross
Journal: J Pharmacol Exp Ther Date: 1976-09 Impact factor: 4.030

8. Location of sites of 5-hydroxytryptamine storage and metabolism by radioautography.

Authors: M D Gershon; L L Ross
Journal: J Physiol Date: 1966-10 Impact factor: 5.182

8 in total

15 in total

Review 1. Receptors of the enteric nervous system: potential targets for drug therapy.

Authors: J Tack
Journal: Gut Date: 2000-12 Impact factor: 23.059

2. Functional Dyspepsia: Impaired Fundic Accommodation.

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Journal: Curr Treat Options Gastroenterol Date: 2000-08

3. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract.

Authors: P R Wade; J Chen; B Jaffe; I S Kassem; R D Blakely; M D Gershon
Journal: J Neurosci Date: 1996-04-01 Impact factor: 6.167

4. Idiopathic Dyspepsia.

Authors: Vincenzo Stanghellini; Elisabetta Poluzzi; Fabrizio De Ponti; Roberto De Giorgio; Giovanni Barbara; Roberto Corinaldesi
Journal: Curr Treat Options Gastroenterol Date: 2005-04

5. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression.

Authors: Y Qian; A Galli; S Ramamoorthy; S Risso; L J DeFelice; R D Blakely
Journal: J Neurosci Date: 1997-01-01 Impact factor: 6.167

10. Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome.

Authors: D A Gorard; G W Libby; M J Farthing
Journal: Dig Dis Sci Date: 1995-01 Impact factor: 3.199