Literature DB >> 6977846

Brain target sites for 1,25-dihydroxyvitamin D3.

W E Stumpf, M Sar, S A Clark, H F DeLuca.   

Abstract

Autoradiographic studies with 3H-labeled 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] demonstrate, in certain neurons of rat forebrain, hindbrain, and spinal cord, a nuclear retention and concentration of radioactivity, which can be prevented by treatment with 1,25(OH)2D3, but not with 25-hydroxyvitamin D3. These results indicate the presence of brain receptors in addition to pituitary receptors for 1,25(OH)2D3 and suggest a central modulation of calcium homeostasis and other central effects for this hormone. The existence of a brain-pituitary axis for certain 1,25(OH)2D3-mediated endocrine-autonomic effects is postulated.

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Year:  1982        PMID： 6977846     DOI： 10.1126/science.6977846

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  43 in total

1.  Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

Authors:  L D Brewer; V Thibault; K C Chen; M C Langub; P W Landfield; N M Porter
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

Review 2.  Hypovitaminosis D in the elderly: from bone to brain.

Authors:  E P Cherniack; H Florez; B A Roos; B R Troen; S Levis
Journal:  J Nutr Health Aging       Date:  2008 Jun-Jul       Impact factor: 4.075

3.  1,25 (OH)2 vitamin D3 sites of action in the brain. An autoradiographic study.

Authors:  W E Stumpf; L P O'Brien
Journal:  Histochemistry       Date:  1987

4.  Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study.

Authors:  Valerie K Wilson; Denise K Houston; Laurel Kilpatrick; James Lovato; Kristine Yaffe; Jane A Cauley; Tamara B Harris; Eleanor M Simonsick; Hilsa N Ayonayon; Stephen B Kritchevsky; Kaycee M Sink
Journal:  J Am Geriatr Soc       Date:  2014-03-17       Impact factor: 5.562

5.  Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study.

Authors:  Jennifer Massa; Katie L Stone; Esther K Wei; Stephanie L Harrison; Elizabeth Barrett-Connor; Nancy E Lane; Misti Paudel; Susan Redline; Sonia Ancoli-Israel; Eric Orwoll; Eva Schernhammer
Journal:  Sleep       Date:  2015-02-01       Impact factor: 5.849

Review 6.  Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms.

Authors:  J Wesley Pike; Seong Min Lee; Mark B Meyer
Journal:  Bonekey Rep       Date:  2014-01-08

7.  Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans.

Authors:  Joong-Seok Kim; Yeong-In Kim; Christopher Song; Injin Yoon; Jeong-Wook Park; Young-Bin Choi; Hee-Tae Kim; Kwang-Soo Lee
Journal:  J Korean Med Sci       Date:  2005-06       Impact factor: 2.153

8.  Nuclear receptor sites for vitamin D-soltriol in midbrain and hindbrain of Siberian hamster (Phodopus sungorus) assessed by autoradiography.

Authors:  W E Stumpf; H J Bidmon; L Li; C Pilgrim; A Bartke; A Mayerhofer; C Heiss
Journal:  Histochemistry       Date:  1992-10

Review 9.  Vitamin D and human health: lessons from vitamin D receptor null mice.

Authors:  Roger Bouillon; Geert Carmeliet; Lieve Verlinden; Evelyne van Etten; Annemieke Verstuyf; Hilary F Luderer; Liesbet Lieben; Chantal Mathieu; Marie Demay
Journal:  Endocr Rev       Date:  2008-08-11       Impact factor: 19.871

10.  Nucleus basalis Meynert neurons contain the vitamin D-induced calcium-binding protein (Calbindin-D 28k).

Authors:  M R Celio; A W Norman
Journal:  Anat Embryol (Berl)       Date:  1985
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