Literature DB >> 6976303

Present status and future prospects for the hybridoma technology.

M D Scharff, S Roberts.   

Abstract

A somatic cell genetic technique has recently been developed that makes it possible to obtain very large amounts of homogeneous antibodies and to replenish the supply of the exact same antibodies whenever they are needed. This hybridoma technology has already contributed to major scientific advances and will surely improve the diagnosis and treatment of many diseases. Because the technology itself is relatively simple and inexpensive, it has captured the attention of basic scientists, clinicians, and industrial managers and investors.

Mesh:

Substances:

Year:  1981        PMID: 6976303     DOI: 10.1007/BF02618605

Source DB:  PubMed          Journal:  In Vitro        ISSN: 0073-5655


  23 in total

1.  Antisera to acute lymphoblastic leukemia cells.

Authors:  M F Greaves; G Brown; N T Rapson; T A Lister
Journal:  Clin Immunol Immunopathol       Date:  1975-05

2.  A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors:  J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

Review 3.  Monoclonal antibodies for analysis of the HLA system.

Authors:  F M Brodsky; P Parham; C J Barnstable; M J Crumpton; W F Bodmer
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

4.  Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class.

Authors:  A Radbruch; B Liesegang; K Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

Review 5.  Monoclonal antibodies: a powerful new tool in biology and medicine.

Authors:  D E Yelton; M D Scharff
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

6.  Somatic variants in mouse myeloma and hybridoma cell lines.

Authors:  D E Yelton; W D Cook; M D Scharff
Journal:  Transplant Proc       Date:  1980-09       Impact factor: 1.066

7.  A better cell line for making hybridomas secreting specific antibodies.

Authors:  M Shulman; C D Wilde; G Köhler
Journal:  Nature       Date:  1978-11-16       Impact factor: 49.962

8.  Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.

Authors:  N Yoshida; R S Nussenzweig; P Potocnjak; V Nussenzweig; M Aikawa
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

9.  Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG.

Authors:  G Galfrè; C Milstein; B Wright
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

10.  Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

Authors:  L Olsson; H S Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.