Literature DB >> 6985745

Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.

N Yoshida, R S Nussenzweig, P Potocnjak, V Nussenzweig, M Aikawa.   

Abstract

Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.

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Year:  1980        PMID： 6985745     DOI： 10.1126/science.6985745

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  158 in total

1.  The cytotoxic T-lymphocyte epitope of the Plasmodium falciparum circumsporozoite protein also modulates the efficiency of receptor-ligand interaction with hepatocytes.

Authors:  D Rathore; T F McCutchan
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for plasmodium sporozoite attachment to target cells.

Authors:  C Pinzon-Ortiz; J Friedman; J Esko; P Sinnis
Journal:  J Biol Chem       Date:  2001-05-14       Impact factor: 5.157

Review 3.  Molecular parasitology: progress towards the development of vaccines for malaria, filariasis, and schistosomiasis.

Authors:  S J Cryz
Journal:  Experientia       Date:  1991-02-15

4.  Pre-erythrocytic stage malaria parasites: non-circumsporozoite protein antigens.

Authors:  M R Hollingdale; M Aikawa; G X Chen; J F Meis; K Sakhuja; B Sina; J D Zhu
Journal:  Bull World Health Organ       Date:  1990       Impact factor: 9.408

5.  Acute malaria prolongs susceptibility of mice to Plasmodium berghei sporozoite infection.

Authors:  A U Orjih
Journal:  Clin Exp Immunol       Date:  1985-07       Impact factor: 4.330

6.  Monoclonal antibodies produced against sporozoites of the human parasite Plasmodium malariae abolish infectivity of sporozoites of the simian parasite Plasmodium brasilianum.

Authors:  A H Cochrane; J W Barnwell; W E Collins; R S Nussenzweig
Journal:  Infect Immun       Date:  1985-10       Impact factor: 3.441

Review 7.  Malaria: immunity and prospects for vaccination.

Authors:  M Hommel
Journal:  West J Med       Date:  1981-10

8.  Monoclonal antibody identifies circumsporozoite protein of Plasmodium malariae and detects a common epitope on Plasmodium brasilianum sporozoites.

Authors:  A H Cochrane; W E Collins; R S Nussenzweig
Journal:  Infect Immun       Date:  1984-09       Impact factor: 3.441

9.  Immunological evaluation of a component isolated from Mycobacterium bovis BCG with a monoclonal antibody to M. bovis BCG.

Authors:  P Minden; P J Kelleher; J H Freed; L D Nielsen; P J Brennan; L McPheron; J K McClatchy
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

10.  Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.

Authors:  Daniel Carapau; Robert Mitchell; Adéla Nacer; Alan Shaw; Caroline Othoro; Ute Frevert; Elizabeth Nardin
Journal:  Infect Immun       Date:  2013-09-16       Impact factor: 3.441
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