Literature DB >> 6971273

The induction of chromosome aberrations in human lymphocytes by in vitro irradiation with alpha-particles from plutonium-239.

R J Purrott, A A Edwards, D C Lloyd, J W Stather.   

Abstract

The yields of unstable chromosome aberrations induced in human lymphocytes by alpha-particles from plutonium-239 have been measured. Plutonium citrate solution was mixed with heparinized blood so that doses of 13--160 rad were delivered in 24 hours. Dicentric aberration yields (Y) fitted best to the linear expression Y = 3 . 72 +/- 0 . 23 x 10(-3) rad-1. Inclusion of a 6 . 5 rad point resulting from a 1 . 7 hour irradiation raised the yield coefficient insignificantly to 3 . 75 +/- 0 . 24 x 10(-3). The aberration yields are in good agreement with data from curium-242 alpha-particles obtained in this laboratory but they are much lower than those obtained in two other laboratories. Reasons for this disagreement are examined.

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Year:  1980        PMID: 6971273     DOI: 10.1080/09553008014551641

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN: 0020-7616


  7 in total

Review 1.  First steps towards systems radiation biology studies concerned with DNA and chromosome structure within living cells.

Authors:  Werner Friedland; Herwig G Paretzke; Francesca Ballarini; Andrea Ottolenghi; Gregor Kreth; Christoph Cremer
Journal:  Radiat Environ Biophys       Date:  2008-01-10       Impact factor: 1.925

2.  Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro alpha-particle irradiation.

Authors:  E Schmid; L Hieber; U Heinzmann; H Roos; A M Kellerer
Journal:  Radiat Environ Biophys       Date:  1996-08       Impact factor: 1.925

3.  DNA damage in non-proliferating cells subjected to ionizing irradiation at high or low dose rates.

Authors:  R K Sachs; P Chen; P Hahnfeldt; D Lai; L R Hlatky
Journal:  J Math Biol       Date:  1993       Impact factor: 2.259

4.  Radiation-induced chromosomal aberrations in the bone marrow of mice exposed to various doses of gamma radiation.

Authors:  G C Jagetia
Journal:  Radiat Environ Biophys       Date:  1993       Impact factor: 1.925

5.  α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients.

Authors:  S Schumann; U Eberlein; C Lapa; J Müller; S Serfling; M Lassmann; H Scherthan
Journal:  Eur J Nucl Med Mol Imaging       Date:  2021-02-04       Impact factor: 9.236

6.  Repair of α-particle-induced DNA damage in peripheral blood mononuclear cells after internal ex vivo irradiation with 223Ra.

Authors:  Lukas Göring; Sarah Schumann; Harry Scherthan; Uta Eberlein; Jessica Müller; Andreas K Buck; Matthias Port; Michael Lassmann
Journal:  Eur J Nucl Med Mol Imaging       Date:  2022-06-27       Impact factor: 10.057

7.  DNA damage in leukocytes after internal ex-vivo irradiation of blood with the α-emitter Ra-223.

Authors:  Sarah Schumann; Uta Eberlein; Razan Muhtadi; Michael Lassmann; Harry Scherthan
Journal:  Sci Rep       Date:  2018-02-02       Impact factor: 4.379

  7 in total

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