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Literature DB >> 6961449

Isolation of a nonmitogenic angiogenesis factor from wound fluid.

M J Banda, D R Knighton, T K Hunt, Z Werb.

Abstract

Angiogenesis, or new capillary growth, is essential to normal growth and wound healing. It is also active in several pathologic states, including the growth of malignant tumors. An extracellular, nonneoplastic angiogenesis factor has been isolated from cell-free rabbit wound fluid by pore-limit dialysis and chromatography on a size-exclusion HPLC column. The isolated angiogenesis factor was purified 9,600-fold with a yield of 81% and has a molecular weight between 2,000 and 14,000. Wound fluid angiogenesis factor was completely separated from the mitogenic activity of wound fluid; it did not increase the number of capillary endothelial cells in vitro or stimulate [3H]thymidine uptake by these cells. The isolated angiogenesis factor stimulated endothelial cell migration in vitro, and less than 200 ng of the factor stimulated angiogenesis in vivo in the corneal implant assay.

Entities: Chemical Disease Species

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Year: 1982 PMID： 6961449 PMCID： PMC347430 DOI： 10.1073/pnas.79.24.7773

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

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Authors: D Gospodarowicz
Journal: J Biol Chem Date: 1975-04-10 Impact factor: 5.157

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Authors: P J Polverini; P S Cotran; M A Gimbrone; E R Unanue
Journal: Nature Date: 1977-10-27 Impact factor: 49.962

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Authors: J M Taylor; W M Mitchell; S Cohen
Journal: J Biol Chem Date: 1974-05-25 Impact factor: 5.157

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Authors: M A Gimbrone; R S Cotran; S B Leapman; J Folkman
Journal: J Natl Cancer Inst Date: 1974-02 Impact factor: 13.506

6. Primary culture of capillary endothelium from rat brain.

Authors: P D Bowman; A L Betz; D Ar; J S Wolinsky; J B Penney; R R Shivers; G W Goldstein
Journal: In Vitro Date: 1981-04

7. Tumor angiogenic factor. Purification from the Walker 256 rat tumor.

Authors: A Fenselau; S Watt; R J Mello
Journal: J Biol Chem Date: 1981-09-25 Impact factor: 5.157

8. Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis.

Authors: D R Knighton; T K Hunt; K K Thakral; W H Goodson
Journal: Ann Surg Date: 1982-10 Impact factor: 12.969

9. Angiogenic activity from bovine retina: partial purification and characterization.

Authors: P A D'Amore; B M Glaser; S K Brunson; A H Fenselau
Journal: Proc Natl Acad Sci U S A Date: 1981-05 Impact factor: 11.205

10. Platelet-derived growth factor in chemotactic for fibroblasts.

Authors: H Seppä; G Grotendorst; S Seppä; E Schiffmann; G R Martin
Journal: J Cell Biol Date: 1982-02 Impact factor: 10.539

25 in total

1. Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in matrigel, collagen, fibrin, and plasma clot.

Authors: R F Nicosia; A Ottinetti
Journal: In Vitro Cell Dev Biol Date: 1990-02

10. Polymerase chain reaction amplification of messages for growth factors in cells from human bronchoalveolar lavage fluids.

Authors: C H Adolff; J A Golden; P W Kennedy; E J Goetzl; C W Turck
Journal: Inflammation Date: 1991-08 Impact factor: 4.092

Isolation of a nonmitogenic angiogenesis factor from wound fluid.

1. Purification of a fibroblast growth factor from bovine pituitary.

2. Studies of fibroplasia in wound healing.

3. Activated macrophages induce vascular proliferation.

4. Characterization of the high molecular weight form of epidermal growth factor.

5. Tumor growth and neovascularization: an experimental model using the rabbit cornea.

6. Primary culture of capillary endothelium from rat brain.

7. Tumor angiogenic factor. Purification from the Walker 256 rat tumor.

8. Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis.

9. Angiogenic activity from bovine retina: partial purification and characterization.

10. Platelet-derived growth factor in chemotactic for fibroblasts.

1. Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in matrigel, collagen, fibrin, and plasma clot.

Review 2. [Chronic wounds. Novel approaches in research and therapy].

3. Comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas.

4. Basic fibroblast growth factor induces angiogenesis in vitro.

5. Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

6. Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization.

7. Characterization and quantification of copper sulfate-induced vascularization of the rabbit cornea.

8. A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

9. Sequential changes in the cell mediators of peritoneal and wound fluids after surgery.

10. Polymerase chain reaction amplification of messages for growth factors in cells from human bronchoalveolar lavage fluids.