Literature DB >> 6955072

Cellular pharmacokinetics of aclacinomycin A in cultured L1210 cells. Comparison with daunorubicin and doxorubicin.

A Zenebergh, R Baurain, A Trouet.   

Abstract

Aclacinomycin, which is more lipophilic than daunorubicin and doxorubicin, is taken up and released more rapidly and extensively by L1210 cells. After 5 h of incubation 91% of aclacinomycin is found in the nuclei of L1210 cells and the drug present in the post-nuclear fraction is distributed between the lysosomes and the cytosol. After an incubation of 5 h aclacinomycin decreases the density of the lysosomes. This effect is not observed either with doxorubicin or daunorubicin or when the cells are incubated with aclacinomycin for only 30 min.

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Year:  1982        PMID： 6955072     DOI： 10.1007/bf00255491

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  23 in total

1.  Mechanism of action of aclacinomycin A. I. The effect on macromolecular syntheses.

Authors:  H Yamaki; H Suzuki; T Nishimura; N Tanaka
Journal:  J Antibiot (Tokyo)       Date:  1978-11       Impact factor: 2.649

2.  Clinical study of aclacinomycin A.

Authors:  M Ogawa; J Inagaki; N Horikoshi; K Inoue; T Chinen; H Ueoka; E Nagura
Journal:  Cancer Treat Rep       Date:  1979-05

Review 3.  Commentary. Lysosomotropic agents.

Authors:  C de Duve; T de Barsy; B Poole; A Trouet; P Tulkens; F Van Hoof
Journal:  Biochem Pharmacol       Date:  1974-09-15       Impact factor: 5.858

4.  Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.

Authors:  K Dano
Journal:  Biochim Biophys Acta       Date:  1973-10-25

5.  DNA-binding parameters of daunorubicin and doxorubicin in the conditions used for studying the interaction of anthracycline-DNA complexes with cells in vitro.

Authors:  Y J Schneider; R Baurain; A Zenebergh; A Trouet
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

6.  Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion.

Authors:  M Masquelier; R Baurain; A Trouet
Journal:  J Med Chem       Date:  1980-11       Impact factor: 7.446

7.  Cellular accumulation and disposition of aclacinomycin A.

Authors:  M J Egorin; R E Clawson; L A Ross; N M Schlossberger; N R Bachur
Journal:  Cancer Res       Date:  1979-11       Impact factor: 12.701

8.  Mutagenicity of aclacinomycin A and daunomycin derivatives.

Authors:  K Umezawa; M Sawamura; T Matsushima; T Sugimura
Journal:  Cancer Res       Date:  1978-06       Impact factor: 12.701

9.  Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

Authors:  M Inaba; H Kobayashi; Y Sakurai; R K Johnson
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

10.  Cellular uptake and metabolism of daunorubicin as determined by high-performance liquid chromatography. Application to L1210 cells.

Authors:  R Baurain; A Zenebergh; A Trouet
Journal:  J Chromatogr       Date:  1978-09-21
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  8 in total

1.  Cellular pharmacology and antitumor activity of N-(p-azidobenzoyl)-daunorubicin, a photoactive anthracycline analogue.

Authors:  S D Averbuch; R E Clawson; N R Bachur; R L Felsted
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

Review 2.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

3.  Hepatic metabolism of doxorubicin in mice and rats.

Authors:  P Vrignaud; D Londos-Gagliardi; J Robert
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Apr-Jun       Impact factor: 2.441

4.  Effect of pH and moderate hyperthermia on doxorubicin, epirubicin and aclacinomycin A cytotoxicity for Chinese hamster ovary cells.

Authors:  L Kleeberger; E M Röttinger
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

5.  In vitro interaction of lithotripter shock waves and cytotoxic drugs.

Authors:  S Gambihler; M Delius
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640

6.  Human hepatoma cells rich in P-glycoprotein are sensitive to aclarubicin and resistant to three other anthracyclines.

Authors:  G Lehne; P De Angelis; O P Clausen; H E Rugstad
Journal:  Br J Cancer       Date:  1996-12       Impact factor: 7.640

7.  Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.

Authors:  R Duncan; P Kopecková-Rejmanová; J Strohalm; I Hume; H C Cable; J Pohl; J B Lloyd; J Kopecek
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640

8.  The in vitro effects and cross-resistance patterns of some novel anthracyclines.

Authors:  P R Twentyman; N E Fox; K A Wright; P Workman; M J Broadhurst; J A Martin; N M Bleehen
Journal:  Br J Cancer       Date:  1986-05       Impact factor: 7.640
  8 in total

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