Literature DB >> 6953447

5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.

G J Schroepfer, E J Parish, A Kisic, E M Jackson, C M Farley, G E Mott.   

Abstract

5 alpha-Cholest-8(14)-en-3 beta-0l-15-one has been found to have significant hypocholesterolemic action on oral administration to baboons at dosages of 50 and 75 mg/kg of body weight. The 15-ketosterol decreased the levels of total serum cholesterol and low density lipoprotein plus very low density lipoprotein (LDL/VLDL) cholesterol and the percentage of total cholesterol associated with LDL/VLDL and increased the percentage of total cholesterol associated with high density lipoprotein (HDL). Moreover, administration of the steroid was associated with an absolute increase in the concentration of HDL cholesterol in those animals with low HDL levels (or with a low percentage of total serum cholesterol in the HDL fraction.

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Year:  1982        PMID： 6953447      PMCID： PMC346345          DOI： 10.1073/pnas.79.9.3042

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  [On a rapid determination of the cholesterol bound to the serum alpha- and beta-lipoproteins].

Authors:  M BURSTEIN; J SAMAILLE
Journal:  Clin Chim Acta       Date:  1960-07       Impact factor: 3.786

2.  A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.

Authors:  L L ABEL; B B LEVY; B B BRODIE; F E KENDALL
Journal:  J Biol Chem       Date:  1952-03       Impact factor: 5.157

3.  Sterol synthesis. Chemical synthesis of 3beta-benzoyloxy -14alpha, 15alpha-epoxy-5alpha-cholest-7-ene, a key intermediate in the synthesis of 15-oxygenated sterols.

Authors:  E J Parish; T E Spike; G J Schroepfer
Journal:  Chem Phys Lipids       Date:  1977-04       Impact factor: 3.329

4.  Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice.

Authors:  G J Schroepfer; D Monger; A S Taylor; J S Chamberlain; E J Parish; A Kisic; A A Kandutsch
Journal:  Biochem Biophys Res Commun       Date:  1977-10-24       Impact factor: 3.575

Review 5.  Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study.

Authors:  W B Kannel; W P Castelli; T Gordon
Journal:  Ann Intern Med       Date:  1979-01       Impact factor: 25.391

6.  14 alpha-Ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells.

Authors:  F D Pinkerton; A Izumi; C M Anderson; L R Miller; A Kisic; G J Schroepfer
Journal:  J Biol Chem       Date:  1982-02-25       Impact factor: 5.157

Review 7.  High density lipoproteins and atherosclerosis.

Authors:  G J Miller
Journal:  Annu Rev Med       Date:  1980       Impact factor: 13.739

8.  Inhibitors of sterol synthesis. Differential effects of 14 alpha-hydroxymethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol and 14 alpha-hydroxymethyl-5 alpha-cholest-6-ene-3 beta, 15 alpha-diol on sterol synthesis in cell-free homogenates of rat liver.

Authors:  L R Miller; R A Pascal; G J Schroepfer
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

9.  Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-C-D ring junction-"5alpha,14beta-cholest-7-en-15alpha-ol-3-one and 5alpha,14beta-cholest-7-en-15beta-ol-3-one.

Authors:  G J Schroepfer; R A Pascal; A A Kandutsch
Journal:  Biochem Pharmacol       Date:  1979       Impact factor: 5.858

10.  Relationship of lipoprotein cholesterol concentrations to experimental atherosclerosis in baboons.

Authors:  H C McGill; C A McMahan; A W Kruski; G E Mott
Journal:  Arteriosclerosis       Date:  1981 Jan-Feb
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  4 in total

1.  Effect of ring-substituted oxysterols on the phase behavior of dipalmitoylphosphatidylcholine membranes.

Authors:  Md Arif Kamal; V A Raghunathan
Journal:  Eur Biophys J       Date:  2012-06-06       Impact factor: 1.733

2.  Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.

Authors:  Hanna Pettersson; Maria Norlin; Ulla Andersson; Irina Pikuleva; Ingemar Björkhem; Alexander Yu Misharin; Kjell Wikvall
Journal:  Biochim Biophys Acta       Date:  2008-06-11

3.  5 alpha-Cholest-8(14)-en-3 beta-ol-15-one lowers serum cholesterol and induces profound changes in the levels of lipoprotein cholesterol and apoproteins in monkeys fed a diet of moderate cholesterol content.

Authors:  G J Schroepfer; B C Sherrill; K S Wang; W K Wilson; A Kisic; T B Clarkson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

4.  Oxysterols: chemical synthesis, biosynthesis and biological activities.

Authors:  E J Parish; V B Nanduri; H H Kohl; F R Taylor
Journal:  Lipids       Date:  1986-01       Impact factor: 1.880
  4 in total

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