Literature DB >> 6952212

Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.

M R Wabl, M Tenkhoff.   

Abstract

We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.

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Year:  1982        PMID： 6952212      PMCID： PMC345794          DOI： 10.1073/pnas.79.2.606

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

Authors:  H Hengartner; T Meo; E Müller
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Allelic exclusion in the B lineage cells of the rabbit.

Authors:  F Loor; A S Kelus
Journal:  Eur J Immunol       Date:  1978-05       Impact factor: 5.532

3.  Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation.

Authors:  F Melchers; J Andersson
Journal:  Transplant Rev       Date:  1973

4.  A system of nomenclature for band patterns of mouse chromosomes.

Authors:  M N Nesbitt; U Francke
Journal:  Chromosoma       Date:  1973       Impact factor: 4.316

5.  Robertsonian chromosomal variation and identification of metacentric chromosomes in feral mice.

Authors:  A Gropp; H Winking; L Zech; H Müller
Journal:  Chromosoma       Date:  1972       Impact factor: 4.316

6.  Surface markers and functional relationships of cells involved in murine B-lymphocyte differentiation.

Authors:  L A Herzenberg; L A Herzenberg; S J Black; M R Loken; K Okumura; W van der Loo; B A Osborne; D Hewgill; J W Goding; G Gutman; N L Warner
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

7.  Chromosomal assignment of the mouse kappa light chain genes.

Authors:  D Swan; P D'Eustachio; L Leinwand; J Seidman; D Keithley; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

8.  Characterization of the domestic horse (Equus caballus) karyotype using G- and C-banding techniques.

Authors:  R A Buckland; J M Fletcher; C Chandley
Journal:  Experientia       Date:  1976-09-15

9.  Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues.

Authors:  B Pernis; G Chiappino; A S Kelus; P G Gell
Journal:  J Exp Med       Date:  1965-11-01       Impact factor: 14.307

10.  Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2.

Authors:  J J Cebra; J E Colberg; S Dray
Journal:  J Exp Med       Date:  1966-03-01       Impact factor: 14.307
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  2 in total

1.  Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

Authors:  G Beck-Engeser; H M Jäck; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

2.  A theory of allelic and isotypic exclusion for immunoglobulin genes.

Authors:  M Wabl; C Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205
  2 in total

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