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Literature DB >> 3103122

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

Abstract

In a pre-B-cell line that rearranges its heavy chain gene segments in vitro, we found that the rate of productive rearrangement on one allele was not influenced by the presence of heavy chain protein encoded by the other allele. This shows that allelic exclusion of heavy chain genes is not regulated at the genetic level.

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Year: 1987 PMID： 3103122 PMCID： PMC304361 DOI： 10.1073/pnas.84.4.1060

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

1. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma.

Authors: R Kleinfield; R R Hardy; D Tarlinton; J Dangl; L A Herzenberg; M Weigert
Journal: Nature Date: 1986 Aug 28-Sep 3 Impact factor: 49.962

2. Allelic inclusion in the pre-B-cell line 18-81.

Authors: M R Wabl; G B Beck-Engeser; P D Burrows
Journal: Proc Natl Acad Sci U S A Date: 1984-02 Impact factor: 11.205

3. Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.

Authors: M R Wabl; M Tenkhoff
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

4. Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.

Authors: P D Burrows; G B Beck; M R Wabl
Journal: Proc Natl Acad Sci U S A Date: 1981-01 Impact factor: 11.205

5. A theory of allelic and isotypic exclusion for immunoglobulin genes.

Authors: M Wabl; C Steinberg
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

6. Inheritance of spontaneous mutability in yeast.

Authors: R C Von Borstel; K T Cain; C M Steinberg
Journal: Genetics Date: 1971-09 Impact factor: 4.562

7. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.

Authors: P D Burrows; G B Beck-Engeser; M R Wabl
Journal: Nature Date: 1983 Nov 17-23 Impact factor: 49.962

8. Transcription of mouse kappa chain genes: implications for allelic exclusion.

Authors: R P Perry; D E Kelley; C Coleclough; J G Seidman; P Leder; S Tonegawa; G Matthyssens; M Weigert
Journal: Proc Natl Acad Sci U S A Date: 1980-04 Impact factor: 11.205

9. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors: F W Alt; N Rosenberg; V Enea; E Siden; D Baltimore
Journal: Mol Cell Biol Date: 1982-04 Impact factor: 4.272

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

1. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma.

2. Allelic inclusion in the pre-B-cell line 18-81.

3. Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.

4. Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.

5. A theory of allelic and isotypic exclusion for immunoglobulin genes.

6. Inheritance of spontaneous mutability in yeast.

7. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.

8. Transcription of mouse kappa chain genes: implications for allelic exclusion.

9. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

10. Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1. Tumorigenesis mediated by an antigen receptor.

Review 2. Allelic exclusion of immunoglobulin genes: models and mechanisms.

3. High rates of deletions in the constant region segment of the immunoglobulin mu gene.

4. Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.

5. Roles of heavy and light chains in IgM polymerization.

6. Immunoglobulin mRNA stability varies during B lymphocyte differentiation.