Literature DB >> 6942419

Is there a difference among human populations in the rate with which mutation produces electrophoretic variants?

J V Neel, E Rothman.   

Abstract

Data are summarized that suggest that tropical-zone/tribal/nonindustrialized populations have higher frequencies of certain types of protein variants than temperate-zone/civilized/industrial populations, and it is demonstrated that these differences are not an artifact produced by the contagious type of sampling used with respect to tribal populations. Evidence is reviewed that suggests that a possible explanation of this difference is higher mutation rates in the tribal populations studied.

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Year:  1981        PMID: 6942419      PMCID: PMC319509          DOI: 10.1073/pnas.78.5.3108

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  21 in total

1.  A genetic study of two French Guiana Amerindian populations. II. Rare electrophoretic variants.

Authors:  P Tchen; J Séger; E Bois; F Grenand; A Fribourg-Blanc; N Feingold
Journal:  Hum Genet       Date:  1978-12-29       Impact factor: 4.132

2.  Founder effect and number of private polymorphisms observed in Amerindian tribes.

Authors:  J V Neel; E A Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

3.  Chromosomal breakage in leukocytes of South American Indians.

Authors:  A D Bloom; J V Neel; T Tsuchimoto; K Meilinger
Journal:  Cytogenet Cell Genet       Date:  1973

4.  The average number of generations until extinction of an individual mutant gene in a finite population.

Authors:  M Kimura; T Ota
Journal:  Genetics       Date:  1969-11       Impact factor: 4.562

5.  Indirect estimates of mutation rates in tribal Amerindians.

Authors:  J V Neel; E D Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

6.  Frequency of private electrophoretic variants and indirect estimates of mutation rate in Papua New Guinea.

Authors:  K K Bhatia; N M Blake; S W Serjeantson; R L Kirk
Journal:  Am J Hum Genet       Date:  1981-01       Impact factor: 11.025

7.  Estimation of mutation rate from rare protein variants.

Authors:  M Nei
Journal:  Am J Hum Genet       Date:  1977-05       Impact factor: 11.025

8.  Mutation rates from rare variants of proteins in Indian tribes.

Authors:  R Chakraborty; A K Roychoudhury
Journal:  Hum Genet       Date:  1978-08-31       Impact factor: 4.132

9.  Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.

Authors:  J V Neel; C Satoh; H B Hamilton; M Otake; K Goriki; T Kageoka; M Fujita; S Neriishi; J Asakawa
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  Let's be scientific about the problem of mutagens in cooked food.

Authors:  T Sugimura
Journal:  Mutat Res       Date:  1978       Impact factor: 2.433

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  6 in total

1.  A revised indirect estimate of mutation rates in Amerindians.

Authors:  J V Neel; H W Mohrenweiser; E D Rothman; J M Naidu
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

2.  A model of weak selection in the infinite alleles framework.

Authors:  E D Rothman; N C Weber
Journal:  J Math Biol       Date:  1986       Impact factor: 2.259

3.  On three methods for estimating mutation rates indirectly.

Authors:  E Pollak
Journal:  Am J Hum Genet       Date:  1986-02       Impact factor: 11.025

4.  Virus-induced gene mutations of eukaryotic cells.

Authors:  E Geissler; M Theile
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

5.  A "disproportion" between the frequency of rare electropmorphs and enzyme deficiency variants in Amerindians.

Authors:  H W Mohrenweiser; J V Neel
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

6.  Frequency of thermostability variants: estimation of total "rare" variant frequency in human populations.

Authors:  H W Mohrenweiser; J V Neel
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

  6 in total

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