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Literature DB >> 6933470

Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.

J V Neel, C Satoh, H B Hamilton, M Otake, K Goriki, T Kageoka, M Fujita, S Neriishi, J Asakawa.

Abstract

A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of "proximally exposed" parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of "distally exposed" parents, who had essentially no radiation exposure.

Entities: Species

Mesh：

Substances：
Enzymes
Proteins

Year: 1980 PMID： 6933470 PMCID： PMC349803 DOI： 10.1073/pnas.77.7.4221

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

1. Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. B. Genetic effects. 2. Cytogenetic study.

Authors: A A Awa
Journal: J Radiat Res Date: 1975-09 Impact factor: 2.724

2. A cohort-type study of survival in the children of parents exposed to atomic bombings.

Authors: H Kato; W J Schull; J V Neel
Journal: Am J Hum Genet Date: 1966-07 Impact factor: 11.025

3. The frequency of private electrophoretic variants in Australian aborigines and indirect estimates of mutation rate.

Authors: K K Bhatia; N M Blake; R L Kirk
Journal: Am J Hum Genet Date: 1979-11 Impact factor: 11.025

4. Dose-response relationship of neutron and gamma rays to chromosomally aberrant cells among atomic bomb survivors in Hiroshima and Nagasaki.

Authors: M Otake
Journal: J Radiat Res Date: 1979-12 Impact factor: 2.724

5. Dose-response relationship of neutrons and gamma rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971.

Authors: T Ishimaru; M Otake; M Ischimaru
Journal: Radiat Res Date: 1979-02 Impact factor: 2.841

6. Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and Nagasaki.

Authors: W J Schull; J V Neel; A Hashizume
Journal: Am J Hum Genet Date: 1966-07 Impact factor: 11.025

7. The frequency in Japanese of genetic variants of 22 proteins. III. Phosphoglucomutase-1, phosphoglucomutase-2, 6-phosphogluconate dehydrogenase, adenylate kinase, and adenosine deaminase.

Authors: C Satoh; R E Ferrell; R J Tanis; N Ueda; S Kishimoto; J V Neel; H B Hamilton; K Baba
Journal: Ann Hum Genet Date: 1977-10 Impact factor: 1.670

8. Mortality in the children of atomic bomb survivors and controls.

Authors: J V Neel; H Kato; W J Schull
Journal: Genetics Date: 1974-02 Impact factor: 4.562

9. The frequency in Japanese of genetic variants of 22 proteins II. Carbonic anhydrase I and II, lactate dehydrogenase, malate dehydrogenase, nucleoside phosphorylase, triose phosphate isomerase, haemoglobin A and haemoglobin A2.

Authors: N Ueda; C Satoh; R J Tanis; R E Ferrell; S Kishimoto; J V Neel; H B Hamilton; K Baba
Journal: Ann Hum Genet Date: 1977-07 Impact factor: 1.670

9. Characterization of two new electrophoretic variants of human triosephosphate isomerase: stability, kinetic, and immunological properties.

Authors: J Asakawa; H W Mohrenweiser
Journal: Biochem Genet Date: 1982-02 Impact factor: 1.890

10. The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.

Authors: J V Neel; W J Schull; A A Awa; C Satoh; H Kato; M Otake; Y Yoshimoto
Journal: Am J Hum Genet Date: 1990-06 Impact factor: 11.025

Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.

1. Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. B. Genetic effects. 2. Cytogenetic study.

2. A cohort-type study of survival in the children of parents exposed to atomic bombings.

3. The frequency of private electrophoretic variants in Australian aborigines and indirect estimates of mutation rate.

4. Dose-response relationship of neutron and gamma rays to chromosomally aberrant cells among atomic bomb survivors in Hiroshima and Nagasaki.

5. Dose-response relationship of neutrons and gamma rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971.

6. Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and Nagasaki.

7. The frequency in Japanese of genetic variants of 22 proteins. III. Phosphoglucomutase-1, phosphoglucomutase-2, 6-phosphogluconate dehydrogenase, adenylate kinase, and adenosine deaminase.

8. Mortality in the children of atomic bomb survivors and controls.

9. The frequency in Japanese of genetic variants of 22 proteins II. Carbonic anhydrase I and II, lactate dehydrogenase, malate dehydrogenase, nucleoside phosphorylase, triose phosphate isomerase, haemoglobin A and haemoglobin A2.

10. Spontaneous mutation rates at enzyme loci in Drosophila melanogaster.

1. Atomic bomb health benefits.

2. Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis.

3. Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report.

4. Heterozygosity and ethnic variation in Japanese platelet proteins.

5. The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides.

6. A revised indirect estimate of mutation rates in Amerindians.

7. Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.

8. Cell proliferation-associated expression of a recently evolved isozyme of triosephosphate isomerase.

9. Characterization of two new electrophoretic variants of human triosephosphate isomerase: stability, kinetic, and immunological properties.

10. The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.