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Literature DB >> 6940833

Characterization of newly established human osteosarcoma cell line, LM-1.

Abstract

The characteristics of Cell Line LM-1, established from a human osteosarcoma, have been studied extensively. The cell produced both bone-specific and placental-like alkaline phosphatases when treated with hydrocortisone 21-phosphate; they had specific membrane antigens tht reacted with sera from osteosarcoma patients. Injection of LM-1 cells into newborn hamsters treated with antilymphocyte serum produced nodular tumors. The characteristics of LM-1 suggest that this tumor cell line has unique features that may be useful in a variety of studies of human and animal osteosarcoma.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6940833 DOI： 10.1007/bf02618142

Source DB: PubMed Journal: In Vitro ISSN： 0073-5655

20 in total

1. C-type virus antigens detected by immunofluorescence in human bone tumour cultures.

Authors: C Zurcher; J Brinkhof; P Bentvelzen; J C De Man
Journal: Nature Date: 1975-04-03 Impact factor: 49.962

2. Placenta-like alkaline phosphatases from human osteosarcoma cells.

Authors: I Singh; K Y Tsang; W S Blakemore
Journal: Cancer Res Date: 1978-01 Impact factor: 12.701

3. Alterations in the mitochondria of human osteosarcoma cells with glucocorticoids.

Authors: I Singh; K Y Tsang; G D Ludwig
Journal: Cancer Res Date: 1974-11 Impact factor: 12.701

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Authors: R M McAllister; M B Gardner; A E Greene; C Bradt; W W Nichols; B H Landing
Journal: Cancer Date: 1971-02 Impact factor: 6.860

5. Human sarcoma cells in culture. Identification by colony-forming ability on monolayers of normal cells.

Authors: S A Aaronson; G J Todaro; A E Freeman
Journal: Exp Cell Res Date: 1970-07 Impact factor: 3.905

6. Two established in vitro cell lines from human mesenchymal tumours.

Authors: J Pontén; E Saksela
Journal: Int J Cancer Date: 1967-09-15 Impact factor: 7.396

7. The relationship between tumorigenicity, growth in agar and fibrinolytic activity in a line of human osteosarcoma cells.

Authors: P A Jones; J S Rhim; H Isaacs; R M McAllister
Journal: Int J Cancer Date: 1975-10-15 Impact factor: 7.396

Characterization of newly established human osteosarcoma cell line, LM-1.

1. C-type virus antigens detected by immunofluorescence in human bone tumour cultures.

2. Placenta-like alkaline phosphatases from human osteosarcoma cells.

3. Alterations in the mitochondria of human osteosarcoma cells with glucocorticoids.

4. Cultivation in vitro of cells derived from a human osteosarcoma.

5. Human sarcoma cells in culture. Identification by colony-forming ability on monolayers of normal cells.

6. Two established in vitro cell lines from human mesenchymal tumours.

7. The relationship between tumorigenicity, growth in agar and fibrinolytic activity in a line of human osteosarcoma cells.

8. Human osteosarcomas: immunologic evidence suggesting an associated infectious agent.

9. The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas.

10. An animal model for human osteosarcoma.

1. Cultivation of human osteosarcoma cell lines in serum-free hormone supplemented medium.