Literature DB >> 1080752

The relationship between tumorigenicity, growth in agar and fibrinolytic activity in a line of human osteosarcoma cells.

P A Jones, J S Rhim, H Isaacs, R M McAllister.   

Abstract

The TE-85 osteosarcoma cell line has several of the in vitro properties of malignant cells, including colony formation in agar, but has low extracellular fibrinolytic activity and no capacity to form tumors in ATS-treated hamsters. Some TE-85 cells clones (clones 2, 4 and 6) have increased fibrinolytic activity but do not form tumors in hamsters. TE-85 cells infected with mammalian transformation-defective viruses have low (FeLV) or increased (RD-114 virus) levels of fibrinolytic activity and do not form tumors in hamsters. TE-85 cell either nonproductively infected with Ki-MSV or productively infected with M-MSV (RD-114), have fibrinolytic activity and can form tumors in hamsters. The MSV gene(s) but not colony formation in agar or extracellular fibrinolytic activity appears to be capable of rendering TE-85 cells tumorigenic in ATS-treated hamsters.

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Year:  1975        PMID： 1080752     DOI： 10.1002/ijc.2910160411

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  16 in total

1.  A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.

Authors:  R S Weiss; R T Javier
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

2.  Osteoblastic and osteolytic human osteosarcomas can be studied with a new xenograft mouse model producing spontaneous metastases.

Authors:  Jun Yuan; Christian Ossendorf; Jan P Szatkowski; James T Bronk; Avudaiappan Maran; Michael Yaszemski; Mark E Bolander; Gobinda Sarkar; Bruno Fuchs
Journal:  Cancer Invest       Date:  2009-05       Impact factor: 2.176

3.  Lack of correlation between tumorigenicity and level of plasminogen activator in fibroblasts transformed by Rous sarcoma virus.

Authors:  B A Wolf; A R Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

4.  Proteolytic and metastatic activities of clones derived from a methylcholanthrene-induced murine fibrosarcoma.

Authors:  M E McLaughlin; I E Liener; N Wang
Journal:  Clin Exp Metastasis       Date:  1983 Oct-Dec       Impact factor: 5.150

5.  The fibrinolytic system. A key to tumor metastasis?

Authors:  J M Malone; S L Wangensteen; W S Moore; K Keown
Journal:  Ann Surg       Date:  1979-09       Impact factor: 12.969

6.  Differentiation of human osteoblastic cells in culture: modulation of proteases by extracellular matrix and tumor necrosis factor-alpha.

Authors:  F S Panagakos; S Kumar
Journal:  Inflammation       Date:  1995-08       Impact factor: 4.092

7.  Modulation of proteases and their inhibitors in immortal human osteoblast-like cells by tumor necrosis factor-alpha in vitro.

Authors:  F S Panagakos; S Kumar
Journal:  Inflammation       Date:  1994-06       Impact factor: 4.092

8.  Formation and mineralization of extracellular matrix secreted by an immortal human osteoblastic cell line: modulation by tumor necrosis factor-alpha.

Authors:  F S Panagakos; L P Hinojosa; S Kumar
Journal:  Inflammation       Date:  1994-06       Impact factor: 4.092

9.  Analysis of malignancy in human cells: malignant and transformed phenotypes are under separate genetic control.

Authors:  E J Stanbridge; J Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

10.  The use of agarose in the determination of anchorage-independent growth.

Authors:  A I Neugut; I B Weinstein
Journal:  In Vitro       Date:  1979-05
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