Literature DB >> 6940133

Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations.

T L Low, S K Hu, A L Goldstein.   

Abstract

The amino acid sequence of thymosin beta 4, a polypeptide isolated from calf thymus, was determined. Thymosin beta 4 is composed of 43 amino acid residues and has a molecular weight of 4982 and an isoelectric point of 5.1. The NH2 terminus of the peptide is blocked by an acetyl group. This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro. Thus, it appears that thymosin beta 4 acts on lymphoid stem cells and may control the early stages of the maturation process of thymus-dependent lymphocytes. This peptide is one of several present in thymosin fraction 5 that participates in the regulation, differentiation, and function of thymus-dependent thymocytes.

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Year:  1981        PMID： 6940133      PMCID： PMC319967          DOI： 10.1073/pnas.78.2.1162

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  T-lymphocyte maturation: cell surface markers and immune function induced by T-lymphocyte cell-free products and thymosin polypeptides.

Authors:  A Ahmed; D M Wong; G B Thurman; T L Low; A L Goldstein; S J Sharkis; I Goldschneider
Journal:  Ann N Y Acad Sci       Date:  1979       Impact factor: 5.691

2.  Development of terminal deoxynucleotidyl transferase activity in embryonic calf thymus gland.

Authors:  L M Chang
Journal:  Biochem Biophys Res Commun       Date:  1971-07-02       Impact factor: 3.575

3.  Reversal by thymosin of increased susceptibility of immunosuppressed mice to Moloney sarcoma virus.

Authors:  M A Hardy; M Zisblatt; N Levine; A L Goldstein; F Lilly; A White
Journal:  Transplant Proc       Date:  1971-03       Impact factor: 1.066

4.  A new convenient method for estimation of total cystine-cysteine in proteins.

Authors:  R L Spencer; F Wold
Journal:  Anal Biochem       Date:  1969-10-15       Impact factor: 3.365

5.  Micro method for detection of formyl and acetyl groups in proteins.

Authors:  G Schmer; G Kreil
Journal:  Anal Biochem       Date:  1969-05       Impact factor: 3.365

6.  The estimation of polypeptide chain molecular weights by gel filtration in 6 M guanidine hydrochloride.

Authors:  W W Fish; K G Mann; C Tanford
Journal:  J Biol Chem       Date:  1969-09-25       Impact factor: 5.157

7.  Acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice.

Authors:  M Zisblatt; A L Goldstein; F Lilly; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

8.  Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).

Authors:  A L Goldstein; F D Slater; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1966-09       Impact factor: 11.205

9.  Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups.

Authors:  R E Offord
Journal:  Nature       Date:  1966-08-06       Impact factor: 49.962

10.  In vitro and in vivo studies with thymosin in cancer patients.

Authors:  L A Schafer; A L Goldstein; J U Gutterman; E M Hersh
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691
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  68 in total

1.  Sequencing of peptides and proteins with blocked N-terminal amino acids: N-acetylserine or N-acetylthreonine.

Authors:  D Wellner; C Panneerselvam; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

2.  The surprising composition of the salivary proteome of preterm human newborn.

Authors:  Massimo Castagnola; Rosanna Inzitari; Chiara Fanali; Federica Iavarone; Alberto Vitali; Claudia Desiderio; Giovanni Vento; Chiara Tirone; Costantino Romagnoli; Tiziana Cabras; Barbara Manconi; Maria Teresa Sanna; Roberto Boi; Elisabetta Pisano; Alessandra Olianas; Mariagiuseppina Pellegrini; Sonia Nemolato; Claus Wilhelm Heizmann; Gavino Faa; Irene Messana
Journal:  Mol Cell Proteomics       Date:  2010-10-13       Impact factor: 5.911

3.  Expression of thymosin beta-4 and related genes in developing human brain.

Authors:  M R Condon; A K Hall
Journal:  J Mol Neurosci       Date:  1992       Impact factor: 3.444

4.  Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.

Authors:  M C Sanders; A L Goldstein; Y L Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

5.  The complete sequences of trout (Salmo gairdneri) thymosin beta 11 and its homologue thymosin beta 12.

Authors:  P P Yialouris; B Coles; O Tsitsiloni; B Schmid; S Howell; A Aitken; W Voelter; A A Haritos
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

6.  Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility.

Authors:  Aase Elisabeth Maelan; Trine Kring Rasmussen; Lars-Inge Larsson
Journal:  Histochem Cell Biol       Date:  2006-06-20       Impact factor: 4.304

7.  Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway.

Authors:  Gabriel Sosne; Ping Qiu; Patricia L Christopherson; Michelle Kurpakus Wheater
Journal:  Exp Eye Res       Date:  2007-01-23       Impact factor: 3.467

8.  Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4.

Authors:  E Hannappel; S Davoust; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

9.  Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues.

Authors:  E Hannappel; G J Xu; J Morgan; J Hempstead; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

10.  In vitro synthesis of thymosin beta 4 encoded by rat spleen mRNA.

Authors:  A W Filipowicz; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205
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