Literature DB >> 6932016

Absence of albumin mRNA in the liver of analbuminemic rats.

H Esumi, M Okui, S Sato, T Sugimura, S Nagase.   

Abstract

Albumin synthesis in the liver of analbuminemic rats, established as a strain from a stock of Sprague-Dawley rats, was examined in vivo by labeling protein by intraperitoneal injection of L-[3H]leucine. Albumin was not synthesized in the liver of analbuminemic rats, whereas its synthesis amounted to about 14% of the total protein synthesis in the liver of normal rats. The RNA content and size distribution of the total polysomes in the liver of analbuminemic rats were not significantly different from those of normal rats. However, no functional mRNA coding for albumin was found in poly(A)-containing RNA from the liver of analbuminemic rats when tested with a cell-free translation system derived from rabbit reticulocytes. Moreover, the amount of the RNA sequence that could hybridize to purified albumin cDNA was more than 750 times greater in the liver of normal rats than in that of analbuminemic rats.

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Year:  1980        PMID： 6932016      PMCID： PMC349585          DOI： 10.1073/pnas.77.6.3215

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Translation of albumin messenger RNA in a cell-free protein-synthesizing system derived from wheat germ.

Authors:  T P Tse; J M Taylor
Journal:  J Biol Chem       Date:  1977-02-25       Impact factor: 5.157

2.  The rat serum albumin gene: analysis of cloned sequences.

Authors:  T D Sargent; J R Wu; J M Sala-Trepat; R B Wallace; A A Reyes; J Bonner
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

3.  Primary activation of the vitellogenin gene in the rooster.

Authors:  R G Deeley; J I Gordon; A T Burns; K P Mullinix; M Binastein; R F Goldberg
Journal:  J Biol Chem       Date:  1977-11-25       Impact factor: 5.157

4.  Use of molecular hybridization to purify and analyze albumin messenger RNA from rat liver.

Authors:  R K Strair; S H Yap; D A Shafritz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

Review 5.  Recent developments in the molecular genetics of human hemoglobin.

Authors:  D J Weatherall; J B Clegg
Journal:  Cell       Date:  1979-03       Impact factor: 41.582

6.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

7.  Turnover of serum proteins in rats with analbuminemia.

Authors:  H Esumi; S Sato; M Okui; T Sugimura; S Nagase
Journal:  Biochem Biophys Res Commun       Date:  1979-04-27       Impact factor: 3.575

8.  An efficient mRNA-dependent translation system from reticulocyte lysates.

Authors:  H R Pelham; R J Jackson
Journal:  Eur J Biochem       Date:  1976-08-01

9.  Albumin-deficient rat mutant.

Authors:  S Nagase; K Shimamune; S Shumiya
Journal:  Science       Date:  1979-08-10       Impact factor: 47.728

10.  Rat liver preproalbumin: in vitro synthesis and partial amino acid sequence.

Authors:  A W Strauss; A M Donohue; C D Bennett; J A Rodkey; A W Alberts
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205
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  10 in total

1.  Exon skipping during splicing of albumin mRNA precursors in Nagase analbuminemic rats.

Authors:  F Shalaby; D A Shafritz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

2.  Fine structure and evolution of the rat serum albumin gene.

Authors:  T D Sargent; L L Jagodzinski; M Yang; J Bonner
Journal:  Mol Cell Biol       Date:  1981-10       Impact factor: 4.272

3.  Bile acid metabolism in analbuminemic rats.

Authors:  A Kambe; K Uchida; H Takase; Y Nomura; Y Adachi
Journal:  Lipids       Date:  1998-01       Impact factor: 1.880

4.  Presence of albumin mRNA precursors in nuclei of analbuminemic rat liver lacking cytoplasmic albumin mRNA.

Authors:  H Esumi; Y Takahashi; T Sekiya; S Sato; S Nagase; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

Review 5.  Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement.

Authors:  P C Walker
Journal:  Clin Pharmacokinet       Date:  1987-07       Impact factor: 6.447

6.  Plasma clearance of sulfobromophthalein and its interaction with hepatic binding proteins in normal and analbuminemic rats: is plasma albumin essential for vectorial transport of organic anions in the liver?

Authors:  M Inoue; K Okajima; S Nagase; Y Morino
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

7.  Original domain for the serum albumin family arose from repeated sequences.

Authors:  S Ohno
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

8.  Effect of post-ischaemic recovery on albumin synthesis and relative amount of translatable albumin messenger RNA in rat liver.

Authors:  G Cairo; L Schiaffonati; M G Aletti; A Bernelli-Zazzera
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

Review 9.  Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism.

Authors:  Hiroyasu Esumi; Takashi Sugimura
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2007-05       Impact factor: 3.493

Review 10.  Chemical carcinogenesis in analbuminemic rats.

Authors:  T Kakizoe; T Sugimura
Journal:  Jpn J Cancer Res       Date:  1988-07
  10 in total

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