Literature DB >> 451621

Albumin-deficient rat mutant.

S Nagase, K Shimamune, S Shumiya.   

Abstract

An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.

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Year:  1979        PMID： 451621     DOI： 10.1126/science.451621

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  55 in total

1.  Extended expression of liver functions of hepatocytes in collagen-contained cell aggregates (cell packs).

Authors:  Y Hirai; K Takebe; M Nakajima; M Takashina; M Iizuka
Journal:  Cytotechnology       Date:  1991-07       Impact factor: 2.058

2.  Marked increases of two kinds of two-exon-skipped albumin mRNAs with aging and their further increase by treatment with 3'-methyl-4-dimethylaminoazobenzene in Nagase analbuminemic rats.

Authors:  T Kaneko; H Shima; H Esumi; M Ochiai; S Nagase; T Sugimura; M Nagao
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

3.  Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver.

Authors:  W B Coleman; K D McCullough; G L Esch; R A Faris; D C Hixson; G J Smith; J W Grisham
Journal:  Am J Pathol       Date:  1997-08       Impact factor: 4.307

4.  Exon skipping during splicing of albumin mRNA precursors in Nagase analbuminemic rats.

Authors:  F Shalaby; D A Shafritz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

Review 5.  In situ imaging of metals in cells and tissues.

Authors:  Reagan McRae; Pritha Bagchi; S Sumalekshmy; Christoph J Fahrni
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

6.  Significance of albumin in the pathogenesis of osteoporosis: bone changes in genetically analbuminemic rats and rats fed a low albumin diet.

Authors:  H Morii; A Shioi; M Inaba; H Goto; T Kawagishi; K Nakatsuka; Y Nishizawa; H Takahashi; H Sone; T Katsumata
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

7.  Presence of albumin mRNA precursors in nuclei of analbuminemic rat liver lacking cytoplasmic albumin mRNA.

Authors:  H Esumi; Y Takahashi; T Sekiya; S Sato; S Nagase; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

8.  A seven-base-pair deletion in an intron of the albumin gene of analbuminemic rats.

Authors:  H Esumi; Y Takahashi; S Sato; S Nagase; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

9.  CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery.

Authors:  Hira Raheel; Siavash Ghaffari; Negar Khosraviani; Victoria Mintsopoulos; Derek Auyeung; Changsen Wang; Yun Hye Kim; Brendan Mullen; Hoon-Ki Sung; May Ho; Gregory Fairn; Dante Neculai; Maria Febbraio; Bryan Heit; Warren L Lee
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2019-01-31       Impact factor: 5.464

10.  Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues.

Authors:  C T Lin; Y F Xu; J Y Wu; L Chan
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808
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