Literature DB >> 6896116

Release of leukotrienes C (LTC) and D (LTD) from inflammatory macrophages during phagocytosis of zymosan and bacteria.

R Roubin, J Benveniste.   

Abstract

Release of slow-reacting substance (SRS) was obtained from resident mouse peritoneal macrophages (R-M phi) upon stimulation with phagocytic stimuli (zymosan, bacteria). The release of SRS from thioglycollate elicited M phi was impaired, whereas that from BCG-elicited M phi was quantitatively unaffected. However, using a high pressure liquid chromatography separation procedure, qualitative variations between SRS released from R-M phi and BCG-M phi were observed. In both cases, LTC was the major component released from M phi, but greater amounts of LTD were released from BCG-M phi than from R-M phi. These data indicate that local environment alters leukotriene generation by M phi.

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Year:  1981        PMID： 6896116     DOI： 10.1007/bf01978749

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Ionophore A 23187-induced production of slow reacting substance of anaphylaxis (SRS-A) by rat peritoneal cells in vitro: evidence for production by mononuclear cells.

Authors:  M K Bach; J R Brashler
Journal:  J Immunol       Date:  1978-03       Impact factor: 5.422

2.  Identification of a component of rat mononuclear cell SRS as leukotriene D.

Authors:  M K Bach; J R Brashler; S Hammarström; B Samuelsson
Journal:  Biochem Biophys Res Commun       Date:  1980-04-29       Impact factor: 3.575

3.  Identification of leukotriene C-1 as a major component of slow-reacting substance from rat mononuclear cells.

Authors:  M K Bach; J R Brashler; S Hammarström; B Samuelsson
Journal:  J Immunol       Date:  1980-07       Impact factor: 5.422

4.  Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity.

Authors:  R A Lewis; J M Drazen; K F Austen; D A Clark; E J Corey
Journal:  Biochem Biophys Res Commun       Date:  1980-09-16       Impact factor: 3.575

5.  Leukotriene C4: isolation from human polymorphonuclear leukocytes.

Authors:  G Hansson; O Rådmark
Journal:  FEBS Lett       Date:  1980-12-15       Impact factor: 4.124

6.  The formation and release of slow reacting substance of anaphylaxis (SRS-A) by rat and mouse peritoneal mononuclear cells induced by ionophore A23187.

Authors:  R P Orange; E G Moore; E W Gelfand
Journal:  J Immunol       Date:  1980-05       Impact factor: 5.422

7.  Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages.

Authors:  U Bretz; B Dewald; T Payne; J Schnyder
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

8.  Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification.

Authors:  L D Yecies; H J Wedner; C W Parker
Journal:  J Immunol       Date:  1979-12       Impact factor: 5.422

9.  Mouse peritoneal macrophages release leukotriene C in response to a phagocytic stimulus.

Authors:  C A Rouzer; W A Scott; Z A Cohn; P Blackburn; J M Manning
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

10.  Dynamics of leukotriene C production by macrophages.

Authors:  C A Rouzer; W A Scott; A L Hamill; Z A Cohn
Journal:  J Exp Med       Date:  1980-11-01       Impact factor: 14.307
  10 in total

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