Literature DB >> 6103909

Identification of leukotriene C-1 as a major component of slow-reacting substance from rat mononuclear cells.

M K Bach, J R Brashler, S Hammarström, B Samuelsson.   

Abstract

Slow-reacting substance (SRS) was produced by rat peritoneal mononuclear cells after stimulation with the ionophore A23187. The SRS consisted of two main components as judged by high-pressure liquid chromatography (HPLC) on Florisil. The larger and more polar component consisted mainly of leukotriene (LT) C-1 as judged by ultraviolet spectroscopy, mass spectrometry (after desulfurization), amino acid analysis, and conversion by soybean lipoxygenase. Comparisons with authentic LTC-1 showed identity on reverse phase HPLC and guinea pig ileum bioassay. The latter methods are known to distinguish between LTC-1 and stereoisomers of LTC-1.

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Year:  1980        PMID： 6103909

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  10 in total

Review 1.  The role of complement in the induction and regulation of immune responses.

Authors:  T G Egwang; A D Befus
Journal:  Immunology       Date:  1984-02       Impact factor: 7.397

2.  The selective release of phospholipase A2 by resident mouse peritoneal macrophages.

Authors:  P D Wightman; M E Dahlgren; P Davies; R J Bonney
Journal:  Biochem J       Date:  1981-11-15       Impact factor: 3.857

3.  Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophages.

Authors:  K Brune; U Aehringhaus; B A Peskar
Journal:  Agents Actions       Date:  1984-06

4.  Stimulation of release of prostaglandins and thromboxanes from isolated guinea pig lung cells by bradykinin, f-Met-Leu-Phe, phorbol myristate, ionophore A23187, and leukotrienes.

Authors:  C Robidoux; J P Pelé; J Maclouf; P Pradelles; P Sirois
Journal:  Inflammation       Date:  1988-08       Impact factor: 4.092

5.  Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii.

Authors:  R M Locksley; J Fankhauser; W R Henderson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

6.  Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

Authors:  S E Dahlén; J Björk; P Hedqvist; K E Arfors; S Hammarström; J A Lindgren; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

7.  Immunoglobulin E-dependent stimulation of human alveolar macrophages: significance in type 1 hypersensitivity.

Authors:  R W Fuller; P K Morris; R Richmond; D Sykes; I M Varndell; D M Kemeny; P J Cole; C T Dollery; J MacDermot
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

8.  Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages.

Authors:  N Feuerstein; M Foegh; P W Ramwell
Journal:  Br J Pharmacol       Date:  1981-03       Impact factor: 8.739

9.  Release of leukotrienes C (LTC) and D (LTD) from inflammatory macrophages during phagocytosis of zymosan and bacteria.

Authors:  R Roubin; J Benveniste
Journal:  Agents Actions       Date:  1981-12

10.  Leukotriene generation by eosinophils.

Authors:  A Jörg; W R Henderson; R C Murphy; S J Klebanoff
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307
  10 in total

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