Literature DB >> 6890669

Structures of the adducts formed between [Pt(dien)Cl]Cl and DNA in vitro.

N P Johnson, J P Macquet, J L Wiebers, B Monsarrat.   

Abstract

The products of the reaction between [Pt(dien)Cl]Cl and salmon sperm DNA have been purified and their structures determined. [Pt(dien)Cl]Cl binds at the N7 position of guanine for levels of fixation below 0.1 platinum per DNA base. Above this level of binding, [Pt(dien)Cl]Cl also reacts at the N7 position of adenine. 1,7-[Pt(dien)]2Ade was observed when more than 0.3 platinum per base were bound to the DNA. Platination at the N7 position of guanosine, unlike alkylation, stabilized the glycosyl linkage and did not lead to fission of the imidazole ring at high pH.

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Year:  1982        PMID： 6890669      PMCID： PMC320869          DOI： 10.1093/nar/10.17.5255

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  16 in total

1.  Correlation between the toxicity of platinum drugs to L1210 leukaemia cells and their mutagenic properties.

Authors:  P Lecointe; J P Macquet; J L Butour
Journal:  Biochem Biophys Res Commun       Date:  1979-09-12       Impact factor: 3.575

2.  Differentiation of DNA-platinum complexes by fluorescence. The use of an intercalating dye as a probe.

Authors:  J L Butour; J P Macquet
Journal:  Eur J Biochem       Date:  1977-09

3.  Relative efficiencies of a series of square-planar plantinum(II) compounds on Salmonella mutagenesis.

Authors:  P Lecointe; J P Macquet; J L Butour; C Paoletti
Journal:  Mutat Res       Date:  1977-04       Impact factor: 2.433

4.  The mechanism of action of antitumor platinum compounds.

Authors:  J J Roberts; A J Thomson
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1979

5.  The properties of 7-methylguanine-containing templates for ribonucleic acid polymerase.

Authors:  D B Ludlum
Journal:  J Biol Chem       Date:  1970-02-10       Impact factor: 5.157

6.  Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosides.

Authors:  J A Zoltewicz; D F Clark; T W Sharpless; G Grahe
Journal:  J Am Chem Soc       Date:  1970-03-25       Impact factor: 15.419

7.  Viscosity, nicking, thermal and alkaline denaturation studies on three classes of DNA-platinum complex.

Authors:  J L Butour; J P Macquet
Journal:  Biochim Biophys Acta       Date:  1981-05-29

8.  Platinum complexes of nucleotides.

Authors:  P C Kong; T Theophanides
Journal:  Bioinorg Chem       Date:  1975

9.  Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples.

Authors:  B Royer-Pokora; L K Gordon; W A Haseltine
Journal:  Nucleic Acids Res       Date:  1981-09-25       Impact factor: 16.971

10.  A circular dichroism study of DNA.platinum complexes. Differentiation between monofunctional, cis-bidentate and trans-bidentate platinum fixation on a series of DNAs.

Authors:  J P Macquet; J L Butour
Journal:  Eur J Biochem       Date:  1978-02
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  7 in total

1.  Polymerase bypass of N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin.

Authors:  Jiayu Ye; Caitlin R Farrington; Julie T Millard
Journal:  Mutat Res       Date:  2018-03-20       Impact factor: 2.433

2.  Repair of cis-platinum-DNA adducts by ABC excinuclease in vivo and in vitro.

Authors:  I Husain; S G Chaney; A Sancar
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

3.  Treatment of DNA with ammonium bicarbonate or thiourea can lead to underestimation of platinum-DNA monoadducts.

Authors:  G R Gibbons; J D Page; S G Chaney
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

4.  Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.

Authors:  Jaroslav Malina; Oldrich Vrana; Viktor Brabec
Journal:  Nucleic Acids Res       Date:  2009-07-09       Impact factor: 16.971

5.  Reaction of cis-diamminedichloroplatinum (II) and DNA in B or Z conformation.

Authors:  J M Malinge; M Leng
Journal:  EMBO J       Date:  1984-06       Impact factor: 11.598

6.  The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G.

Authors:  R M Wing; P Pjura; H R Drew; R E Dickerson
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598

7.  Production of platinum atom nanoclusters at one end of helical plant viruses.

Authors:  Yuri Drygin; Olga Kondakova; Joseph Atabekov
Journal:  Adv Virol       Date:  2013-09-25
  7 in total

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