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Literature DB >> 6889885

Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus.

Abstract

4-(Hydroxymethyl-benzenediazonium tetrafluoroborate was administered as a single intragastric instillation at 400 micrograms/g to Swiss albino mice. The treatment gave rise to glandular stomach tumours in incidences of 30% in females and 32% in males. Histopathologically, the tumours were classified as polypoid adenomas and adenocarcinomas. This diazonium ion is an ingredient of the cultivated mushroom of commerce, Agaricus bisporus. The implications are self-evident.

Entities: Chemical Species

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Year: 1982 PMID： 6889885 PMCID： PMC2011129 DOI： 10.1038/bjc.1982.218

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

9 in total

1. Sequential morphological changes in N-methyl-N'-nitro-N-nitrosoguanidine carcinogenesis in the glandular stomach of rats.

Authors: T Saito; K Inokuchi; S Takayama; T Sugimura
Journal: J Natl Cancer Inst Date: 1970-04 Impact factor: 13.506

2. ISOLATION AND STRUCTURE OF AGARITINE, A GAMMA-GLUTAMYL-SUBSTITUTED ARYLHYDRAZINE DERIVATIVE FROM AGARICACEAE.

Authors: B LEVENBERG
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

3. ENZYMATIC TRANSFER OF THE GAMMA-GLUTAMYL GROUP BETWEEN NATURALLY OCCURRING ANILINE AND PHENYLHYDRAZINE DERIVATIVES IN THE GENUS AGARICUS.

Authors: H J GIGLIOTTI; B LEVENBERG
Journal: Biochim Biophys Acta Date: 1964-03-09

4. Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: T Sugimura; S Fujimura
Journal: Nature Date: 1967-12-02 Impact factor: 49.962

5. Carcinogenesis of 4-(hydroxymethyl)benzenediazonium ion (tetrafluoroborate) of Agaricus bisporus.

Authors: B Toth; K Patil; H S Jae
Journal: Cancer Res Date: 1981-06 Impact factor: 12.701

6. Tumor induction with the N'-acetyl derivative of 4-hydroxymethyl-phenylhydrazine, a metabolite of agaritine of Agaricus bisporus.

Authors: B Toth; D Nagel; K Patil; J Erickson; K Antonson
Journal: Cancer Res Date: 1978-01 Impact factor: 12.701

3 in total

Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus.

1. Sequential morphological changes in N-methyl-N'-nitro-N-nitrosoguanidine carcinogenesis in the glandular stomach of rats.

2. ISOLATION AND STRUCTURE OF AGARITINE, A GAMMA-GLUTAMYL-SUBSTITUTED ARYLHYDRAZINE DERIVATIVE FROM AGARICACEAE.

3. ENZYMATIC TRANSFER OF THE GAMMA-GLUTAMYL GROUP BETWEEN NATURALLY OCCURRING ANILINE AND PHENYLHYDRAZINE DERIVATIVES IN THE GENUS AGARICUS.

4. Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine.

5. Carcinogenesis of 4-(hydroxymethyl)benzenediazonium ion (tetrafluoroborate) of Agaricus bisporus.

6. Tumor induction with the N'-acetyl derivative of 4-hydroxymethyl-phenylhydrazine, a metabolite of agaritine of Agaricus bisporus.

7. Attempted tumor induction with agaritine in mice.

8. Evidence for the occurrence and formation of diazonium ions in the Agaricus bisporus mushroom and its extracts.

9. An aromatic diazonium compound in the mushroom Agaricus bisporus.

1. Lack of carcinogenicity of agaritine by subcutaneous administration in mice.

2. Agaricus bisporus: an assessment of its carcinogenic potency.

Review 3. Past, present, and future of mutagens in cooked foods.