Literature DB >> 6873240

Time course study of the changes in blood glutathione induced by acute ethanol intoxication in the rat.

V Fernández, N Fernández, A Valenzuela, L A Videla.   

Abstract

Acute ethanol treatment of rats (5 g/kg) has a biphasic effect on the glutathione content of the erythrocyte. After 3 h of intoxication there is a diminution in total GSH equivalents, followed by a recovery to basal values 6 h after treatment. The decrease of total GSH equivalents is mainly due to a diminution of the oxidized form of the tripeptide. Concomitantly a marked increase in the plasma level of glutathione was found at 3 h, followed by a diminution to values obtained at time zero.

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Year:  1983        PMID： 6873240     DOI： 10.1007/bf01990416

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Changes in glutathione in acute and chronic alcohol intoxication.

Authors:  C Guerri; S Grisolía
Journal:  Pharmacol Biochem Behav       Date:  1980       Impact factor: 3.533

3.  On the mechanism of the glutathione depletion induced in the liver by acute ethanol ingestion.

Authors:  L A Videla; V Fernández; N Fernández; A Valenzuela
Journal:  Subst Alcohol Actions Misuse       Date:  1981

4.  Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.

Authors:  H Rottenberg; A Waring; E Rubin
Journal:  Science       Date:  1981-07-31       Impact factor: 47.728

5.  Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the rat.

Authors:  L A Videla; V Fernandez; G Ugarte; A Valenzuela
Journal:  FEBS Lett       Date:  1980-02-25       Impact factor: 4.124

6.  Transport of glutathione S-conjugate from human erythrocytes.

Authors:  P G Board
Journal:  FEBS Lett       Date:  1981-02-23       Impact factor: 4.124

7.  Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat.

Authors:  V Fernández; L A Videla
Journal:  Experientia       Date:  1981-04-15

8.  Assay, purification, properties and mechanism of action of gamma-glutamylcysteine synthetase from the liver of the rat and Xenopus laevis.

Authors:  J S Davis; J B Balinsky; J S Harington; J B Shepherd
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857
  8 in total
  2 in total

1.  Conjugation of acetaldehyde with cysteinylglycine, the first metabolite in glutathione breakdown by gamma-glutamyltranspeptidase.

Authors:  Y Kera; T Kiriyama; S Komura
Journal:  Agents Actions       Date:  1985-10

2.  Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Turnover studies.

Authors:  H Speisky; A MacDonald; G Giles; H Orrego; Y Israel
Journal:  Biochem J       Date:  1985-02-01       Impact factor: 3.857
  2 in total

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