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Literature DB >> 6264608

Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.

Abstract

Membrane binding of ethanol, anesthetics, and hydrophobic molecules in brain synaptosomes and liver mitochondria from rats is conspicuously reduced after long-term consumption of ethanol. The membranes are resistant to structural disordering by both ethanol and halothane. Tolerance, cross-tolerance, and dependence in chronic alcoholics may in part result from membrane alterations that inhibit the binding of ethanol and other drugs.

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Year: 1981 PMID： 6264608 DOI： 10.1126/science.6264608

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

27 in total

1. Ethanol in human brain by magnetic resonance spectroscopy: correlation with blood and breath levels, relaxation, and magnetization transfer.

Authors: G Fein; D J Meyerhoff
Journal: Alcohol Clin Exp Res Date: 2000-08 Impact factor: 3.455

2. The molecular basis of alcohol tolerance and drug cross-tolerance in chronic alcoholism.

Authors: H Rottenberg; A Waring; E Rubin
Journal: Biophys J Date: 1982-01 Impact factor: 4.033

3. Effects of brain membranes on 1H nuclear magnetic resonance signal intensity of ethanol in vitro.

Authors: V Govindaraju; D J Meyerhoff; A A Maudsley; M Vermathen; M W Weiner
Journal: Alcohol Alcohol Date: 1997 Nov-Dec Impact factor: 2.826

4. Saturable binding of halothane to rat brain synaptosomes.

Authors: E A el-Maghrabi; R G Eckenhoff; H Shuman
Journal: Proc Natl Acad Sci U S A Date: 1992-05-15 Impact factor: 11.205

5. Effects of psychotropic agents on the physical properties of platelet membranes in vitro.

Authors: G S Zubenko; B M Cohen
Journal: Psychopharmacology (Berl) Date: 1985 Impact factor: 4.530

6. Mechanism of ethanol inhibition of fermentation in Zymomonas mobilis CP4.

Authors: Y A Osman; L O Ingram
Journal: J Bacteriol Date: 1985-10 Impact factor: 3.490

7. Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment.

Authors: F Cardellach; T F Taraschi; J S Ellingson; C D Stubbs; E Rubin; J B Hoek
Journal: Biochem J Date: 1991-03-01 Impact factor: 3.857