Literature DB >> 6870836

Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one with dihydropteridine reductase.

W L Armarego, D Randles, H Taguchi.   

Abstract

The Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one were determined for dihydropteridine reductase (EC 1.6.99.10) from two sources. The parameters of the pterin are of the same order as those of the most effective substrates of dihydropteridine reductase. The Km values of the pterin are one order of magnitude smaller than those of the pyrimidinone, although the kcat. values are of the same order.

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Year:  1983        PMID： 6870836      PMCID： PMC1154367          DOI： 10.1042/bj2110357

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  A highly stereospecific synthesis of (R)- and (S)-[2-3H]Glycine.

Authors:  W L Armarego; B A Milloy; W Pendergast
Journal:  J Chem Soc Perkin 1       Date:  1976

2.  The activity of 2,4,5-triamino-6-hydroxypyrimidine in the phenylalanine hydroxylase system.

Authors:  S Kaufman
Journal:  J Biol Chem       Date:  1979-06-25       Impact factor: 5.157

3.  The isolation and characterization of dihydropteridine reductase from sheep liver.

Authors:  J E Craine; E S Hall; S Kaufman
Journal:  J Biol Chem       Date:  1972-10-10       Impact factor: 5.157

4.  Dihydropteridine reductase. A method for the measurement of activity, and investigations of the specificity for NADH and NADPH.

Authors:  K H Nielsen; V Simonsen; K E Lind
Journal:  Eur J Biochem       Date:  1969-07

5.  Fitting of enzyme kinetic data without prior knowledge of weights.

Authors:  A Cornish-Bowden; L Endrenyi
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857

6.  Hydrogen transfer from 4-R and 4-S (4-3H) NADH in the reduction of d,l-cis-6,7-dimethyl-6,7 (8H) dihydropterin with dihydropteridine reductase from human liver and sheep liver.

Authors:  W L Armarego
Journal:  Biochem Biophys Res Commun       Date:  1979-07-12       Impact factor: 3.575

7.  Rearrangement of quinonoid dihydropteridines to 7,8-dihydropteridines.

Authors:  M C Archer; K G Scrimgeour
Journal:  Can J Biochem       Date:  1970-03

8.  Human dihydropteridine reductase: a method for the measurement of activity in cultured cells, and its application to malignant hyperphenylalaninemia.

Authors:  F A Firgaira; R G Cotton; D M Danks
Journal:  Clin Chim Acta       Date:  1979-07-02       Impact factor: 3.786

9.  Inhibition of dihydropteridine reductase by dopamine.

Authors:  S E Purdy; J A Blair; P A Barford
Journal:  Biochem J       Date:  1981-06-01       Impact factor: 3.857

10.  Isolation and characterization of dihydropteridine reductase from human liver.

Authors:  F A Firgaira; R G Cotton; D M Danks
Journal:  Biochem J       Date:  1981-07-01       Impact factor: 3.857
  10 in total
  3 in total

1.  Dihydropteridine reductase from Escherichia coli.

Authors:  S G Vasudevan; D C Shaw; W L Armarego
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

2.  Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice.

Authors:  Natasha Sienkiewicz; Han B Ong; Alan H Fairlamb
Journal:  Mol Microbiol       Date:  2010-06-01       Impact factor: 3.501

3.  New pteridine substrates for dihydropteridine reductase and horseradish peroxidase.

Authors:  W L Armarego; A Ohnishi; H Taguchi
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857
  3 in total

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